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RNF11 ring finger protein 11 [ Homo sapiens (human) ]

Gene ID: 26994, updated on 29-Mar-2020

Summary

Official Symbol
RNF11provided by HGNC
Official Full Name
ring finger protein 11provided by HGNC
Primary source
HGNC:HGNC:10056
See related
Ensembl:ENSG00000123091 MIM:612598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-123; SID1669
Summary
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 55.4) and 25 other tissues See more
Orthologs

Genomic context

See RNF11 in Genome Data Viewer
Location:
1p32.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (51236273..51273447)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (51701945..51739119)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cofilin 1 pseudogene 2 Neighboring gene mitochondrial import receptor subunit TOM5 homolog pseudogene Neighboring gene long intergenic non-protein coding RNA 1562 Neighboring gene ribosomal protein S2 pseudogene 8 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene uncharacterized LOC105378717 Neighboring gene TTC39A antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014372.5NP_055187.1  RING finger protein 11

    See identical proteins and their annotated locations for NP_055187.1

    Status: REVIEWED

    Source sequence(s)
    AA224090, BC020964, BC036670, BC047654, DB265274, DB564333
    Consensus CDS
    CCDS556.1
    UniProtKB/Swiss-Prot
    Q9Y3C5
    Related
    ENSP00000242719.3, ENST00000242719.4
    Conserved Domains (1) summary
    cd16468
    Location:98140
    RING-H2_RNF11; RING finger, H2 subclass, found in RING finger protein 11 (RNF11) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    51236273..51273447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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