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AKAP8L A-kinase anchoring protein 8 like [ Homo sapiens (human) ]

Gene ID: 26993, updated on 9-Feb-2020

Summary

Official Symbol
AKAP8Lprovided by HGNC
Official Full Name
A-kinase anchoring protein 8 likeprovided by HGNC
Primary source
HGNC:HGNC:29857
See related
Ensembl:ENSG00000011243 MIM:609475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA95; HAP95; NAKAP; NAKAP95
Expression
Ubiquitous expression in bone marrow (RPKM 21.2), testis (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See AKAP8L in Genome Data Viewer
Location:
19p13.12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15380050..15418988, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15490859..15529916, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene A-kinase anchoring protein 8 Neighboring gene Sharpr-MPRA regulatory region 9920 Neighboring gene WIZ zinc finger Neighboring gene microRNA 1470 Neighboring gene RAS protein activator like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HAP95 is incorporated into HIV-1 Gag/Gag-Pol virus-like particle instead of HIV-1 Gag virus-like particle, suggesting a role of Pol in the incorporation of HAP95 into virus particles PubMed
Vif vif HIV-1 Vif is identified to have a physical interaction with A kinase (PRKA) anchor protein 8-like (AKAP8L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
reverse transcriptase gag-pol Co-immunoprecipitation assay demonstrates that HIV-1 RT/p66 associates with HAP95 in vitro PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434L0650

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DEAD/H-box RNA helicase binding TAS
Traceable Author Statement
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
lamin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear envelope disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
A-kinase anchor protein 8-like
Names
A kinase (PRKA) anchor protein 8-like
AKAP8-like protein
helicase A-binding protein 95 kDa
homologous to AKAP95 protein
neighbor of A-kinase anchoring protein 95
neighbor of AKAP95
testis tissue sperm-binding protein Li 90mP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291478.2NP_001278407.1  A-kinase anchor protein 8-like isoform 2

    See identical proteins and their annotated locations for NP_001278407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK295956, BQ006924
    Consensus CDS
    CCDS77249.1
    UniProtKB/Swiss-Prot
    Q9ULX6
    Related
    ENSP00000470952.1, ENST00000595465.6
    Conserved Domains (1) summary
    pfam04988
    Location:328492
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
  2. NM_014371.4NP_055186.3  A-kinase anchor protein 8-like isoform 1

    See identical proteins and their annotated locations for NP_055186.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ243467, BQ006924, DA315789
    Consensus CDS
    CCDS46005.1
    UniProtKB/Swiss-Prot
    Q9ULX6
    Related
    ENSP00000380557.3, ENST00000397410.10
    Conserved Domains (1) summary
    pfam04988
    Location:389553
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

  1. NR_111971.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK094736, BF973758, BQ006924, CD244113, DA315789
    Related
    ENST00000609519.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15380050..15418988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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