Clec4a1 C-type lectin domain family 4, member a1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4a1provided by MGI
Official Full Name: C-type lectin domain family 4, member a1provided by MGI
Primary source: MGI:MGI:3036291
See related: Ensembl:ENSMUSG00000049037 AllianceGenome:MGI:3036291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dcir4
Summary: Predicted to enable calcium ion binding activity and mannose binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 3.8), liver E18 (RPKM 3.6) and 22 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6; 6 F2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122898807..122911578)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122921848..122934619)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The anti- DCIR3 antibody established in this study, together with the previously established anti-DCIR1 and anti-DCIR4 antibodies, would be a valuable tool to investigate biology and pathophysiology of monocytes.
Title: DCIR3 and DCIR4 are co-expressed on inflammatory and patrolling monocytes.
DCIR4 is preferentially expressed on the two major populations of monocytes: inflammatory and patrolling monocytes.
Title: Dendritic cell inhibitory receptor 4 (DCIR4) is preferentially expressed on inflammatory and patrolling monocytes.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Homologs of the Clec4a1 gene: The Clec4a1 gene is conserved in human, chimpanzee, and rat.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: C-type lectin domain family 4, member a1

Names: dendritic cell inhibitory receptor 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199311.2 → NP_955015.1 C-type lectin domain family 4, member a1

See identical proteins and their annotated locations for NP_955015.1

Status: VALIDATED

Source sequence(s)

BC049354, CK626014

Consensus CDS

CCDS20507.1

UniProtKB/TrEMBL

Q80UI7

Related

ENSMUSP00000062441.9, ENSMUST00000060484.9

Conserved Domains (1) summary

cd03590
Location:114 → 240

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)