Clip2 CAP-GLY domain containing linker protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clip2provided by MGI
Official Full Name: CAP-GLY domain containing linker protein 2provided by MGI
Primary source: MGI:MGI:1313136
See related: Ensembl:ENSMUSG00000063146 AllianceGenome:MGI:1313136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clip1; Cyln2; WSCR4; wbscr4; CLIP-115; mKIAA0291; B230327O20
Summary: Enables microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in microtubule plus-end. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb; and trigeminal nerve. Used to study Williams-Beuren syndrome. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 28.5), CNS E18 (RPKM 28.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 74.63 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (134518237..134582922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (134489383..134553767, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Williams Syndrome is caused by a variety of genes and that heterozygous deletion of CYLN2 is one of the major causes
Title: Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.
evidence that mice with haploinsufficiency for Cyln2 have features reminiscent of Williams syndrome, including mild growth deficiency, brain abnormalities, hippocampal dysfunction and particular deficits in motor coordination
Title: Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cyln2 (e-PCR), detects polymorphism
- UniSTS:228483

Homology

Homologs of the Clip2 gene: The Clip2 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Clip2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendritic microtubule	ISO Inferred from Sequence Orthology more info
located_in lamellar body	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: CAP-Gly domain-containing linker protein 2

Names: cytoplasmic linker protein 1, 115 kDa; cytoplasmic linker protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039162.2 → NP_001034251.1 CAP-Gly domain-containing linker protein 2 isoform b

See identical proteins and their annotated locations for NP_001034251.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.

Source sequence(s)

BC053048, BC121191

Consensus CDS

CCDS39309.1

UniProtKB/Swiss-Prot

Q9Z0H8

Related

ENSMUSP00000037431.7, ENSMUST00000036999.10

Conserved Domains (4) summary

TIGR04527
Location:537 → 623

mycoplas_twoTM; two transmembrane protein

pfam01302
Location:223 → 286

CAP_GLY; CAP-Gly domain

pfam10212
Location:648 → 836

TTKRSYEDQ; Predicted coiled-coil domain-containing protein

pfam13863
Location:358 → 452

DUF4200; Domain of unknown function (DUF4200)
NM_009990.3 → NP_034120.2 CAP-Gly domain-containing linker protein 2 isoform a

See identical proteins and their annotated locations for NP_034120.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK045967, BC053048, BC121191

Consensus CDS

CCDS39310.1

UniProtKB/Swiss-Prot

Q9EP81, Q9Z0H8

Related

ENSMUSP00000098212.3, ENSMUST00000100647.7

Conserved Domains (2) summary

COG1196
Location:357 → 1016

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:222 → 286

CAP_GLY; CAP-Gly domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

134518237..134582922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165158.1 → XP_036021051.1 CAP-Gly domain-containing linker protein 2 isoform X1

Conserved Domains (2) summary

COG5244
Location:220 → 853

NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:222 → 286

CAP_GLY; CAP-Gly domain