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Pla2g2f phospholipase A2, group IIF [ Mus musculus (house mouse) ]

Gene ID: 26971, updated on 27-Nov-2024

Summary

Official Symbol
Pla2g2fprovided by MGI
Official Full Name
phospholipase A2, group IIFprovided by MGI
Primary source
MGI:MGI:1349661
See related
Ensembl:ENSMUSG00000028749 AllianceGenome:MGI:1349661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIIFsPLA2; sPLA2-IIF
Summary
Enables phospholipase A2 activity. Involved in arachidonate metabolic process and phosphatidylethanolamine acyl-chain remodeling. Acts upstream of or within negative regulation of T cell proliferation and phospholipid metabolic process. Predicted to be located in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and urinary system. Orthologous to human PLA2G2F (phospholipase A2 group IIF). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in adrenal adult (RPKM 28.5), colon adult (RPKM 24.7) and 6 other tissues See more
Orthologs
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Genomic context

See Pla2g2f in Genome Data Viewer
Location:
4 D3; 4 70.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138477842..138484932, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138750533..138757598, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32770 Neighboring gene STARR-seq mESC enhancer starr_11814 Neighboring gene UBX domain protein 10 Neighboring gene phospholipase A2, group IIC Neighboring gene predicted gene, 57720 Neighboring gene predicted gene, 42332 Neighboring gene predicted gene, 32871 Neighboring gene phospholipase A2, group IID

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylglycerol acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylserine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
group IIF secretory phospholipase A2
Names
GIIF sPLA2
phosphatidylcholine 2-acylhydrolase 2F
NP_001347804.1
NP_036175.2
XP_036020061.1
XP_036020062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360875.2NP_001347804.1  group IIF secretory phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1a) reflects the use of an in-frame downstream start codon for translation, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus with a predicted signal peptide, compared to isoform 1. With the available data, it is not clear which start codon is most likely used.
    Source sequence(s)
    AL844178
    UniProtKB/Swiss-Prot
    Q8CE14, Q9QZT4
    Conserved Domains (1) summary
    cd00125
    Location:21138
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. NM_012045.5NP_036175.2  group IIF secretory phospholipase A2 isoform 1

    See identical proteins and their annotated locations for NP_036175.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a longer protein (isoform 1), which lacks a signal peptide. With the available data, it is not clear which start codon is most likely used.
    Source sequence(s)
    AL844178
    Consensus CDS
    CCDS18832.1
    UniProtKB/Swiss-Prot
    Q9QZT4
    Related
    ENSMUSP00000030526.7, ENSMUST00000030526.7
    Conserved Domains (1) summary
    cd00125
    Location:63180
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138477842..138484932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164168.1XP_036020061.1  group IIF secretory phospholipase A2 isoform X1

    Conserved Domains (1) summary
    cd00125
    Location:14131
    PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
  2. XM_036164169.1XP_036020062.1  group IIF secretory phospholipase A2 isoform X2

    Conserved Domains (1) summary
    cl05417
    Location:63145
    PLA2_like; Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...