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Pla2g2e phospholipase A2, group IIE [ Mus musculus (house mouse) ]

Gene ID: 26970, updated on 27-Nov-2024

Summary

Official Symbol
Pla2g2eprovided by MGI
Official Full Name
phospholipase A2, group IIEprovided by MGI
Primary source
MGI:MGI:1349660
See related
Ensembl:ENSMUSG00000028751 AllianceGenome:MGI:1349660
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calcium-dependent phospholipase A2 activity. Involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Acts upstream of or within low-density lipoprotein particle remodeling. Located in extracellular region. Is expressed in several structures, including alimentary system; cranium; heart; respiratory system; and telencephalon. Orthologous to human PLA2G2E (phospholipase A2 group IIE). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 4.5), genital fat pad adult (RPKM 2.9) and 8 other tissues See more
Orthologs
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Genomic context

See Pla2g2e in Genome Data Viewer
Location:
4 D3; 4 70.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138605253..138610125)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138877911..138882817)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:138422386-138422686 Neighboring gene predicted gene, 32930 Neighboring gene predicted gene 13030 Neighboring gene OTU domain containing 3 Neighboring gene predicted gene, 18097

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
group IIE secretory phospholipase A2
Names
GIIE sPLA2
mGIIEsPLA2s
phosphatidylcholine 2-acylhydrolase 2E
sPLA2-IIE
NP_036174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012044.2NP_036174.1  group IIE secretory phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_036174.1

    Status: PROVISIONAL

    Source sequence(s)
    AL844178
    Consensus CDS
    CCDS18835.1
    UniProtKB/Swiss-Prot
    Q9QUL3
    UniProtKB/TrEMBL
    Q3UG05
    Related
    ENSMUSP00000030531.8, ENSMUST00000030531.14
    Conserved Domains (1) summary
    pfam00068
    Location:23127
    Phospholip_A2_1; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138605253..138610125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)