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GIPR gastric inhibitory polypeptide receptor [ Homo sapiens (human) ]

Gene ID: 2696, updated on 3-Apr-2024

Summary

Official Symbol
GIPRprovided by HGNC
Official Full Name
gastric inhibitory polypeptide receptorprovided by HGNC
Primary source
HGNC:HGNC:4271
See related
Ensembl:ENSG00000010310 MIM:137241; AllianceGenome:HGNC:4271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGQTL2
Summary
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Expression
Broad expression in stomach (RPKM 5.3), fat (RPKM 1.5) and 16 other tissues See more
Orthologs
NEW
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Genomic context

See GIPR in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45668221..45683722)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48495760..48511255)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46171479..46186980)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene EMAP like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46145740-46146591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46148647-46149146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10786 Neighboring gene EML2 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46150807-46151667 Neighboring gene RNA, 7SL, cytoplasmic 836, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46173596-46174114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46174115-46174633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14811 Neighboring gene microRNA 642a Neighboring gene microRNA 642b Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46194747-46195467 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46196081-46196631 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene glutaminyl-peptide cyclotransferase like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
EBI GWAS Catalog
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Meta-analysis identifies common variants associated with body mass index in east Asians.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gastric inhibitory peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gastric inhibitory peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucagon family peptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in gastric inhibitory peptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gastric inhibitory polypeptide receptor
Names
GIP-R
glucose-dependent insulinotropic polypeptide receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000164.4NP_000155.1  gastric inhibitory polypeptide receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_000155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006132, AC007191, BM129443, BU784011, U39231
    Consensus CDS
    CCDS12671.1
    UniProtKB/Swiss-Prot
    B7WP14, B7ZKQ0, P48546, Q14401, Q16400, Q52M04, Q9UPI1
    UniProtKB/TrEMBL
    Q4VBP1
    Related
    ENSP00000467494.1, ENST00000590918.6
    Conserved Domains (2) summary
    smart00008
    Location:57126
    HormR; Domain present in hormone receptors
    cd15929
    Location:134409
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_001308418.2NP_001295347.1  gastric inhibitory polypeptide receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001295347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC006132, AC007191, BC143300, BM129443, BU784011, U39231
    Consensus CDS
    CCDS82367.1
    UniProtKB/TrEMBL
    Q4VBP1
    Related
    ENSP00000305321.8, ENST00000304207.12
    Conserved Domains (2) summary
    pfam00002
    Location:98352
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl02422
    Location:4990
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45668221..45683722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438600.1XP_047294556.1  gastric inhibitory polypeptide receptor isoform X3

    UniProtKB/Swiss-Prot
    B7WP14, B7ZKQ0, P48546, Q14401, Q16400, Q52M04, Q9UPI1
  2. XM_047438599.1XP_047294555.1  gastric inhibitory polypeptide receptor isoform X2

  3. XM_011526710.3XP_011525012.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_011525012.1

    UniProtKB/TrEMBL
    Q4VBP1
    Conserved Domains (2) summary
    pfam00002
    Location:134430
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
  4. XM_011526709.3XP_011525011.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_011525011.1

    UniProtKB/TrEMBL
    Q4VBP1
    Conserved Domains (2) summary
    pfam00002
    Location:134430
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
  5. XM_011526713.3XP_011525015.1  gastric inhibitory polypeptide receptor isoform X4

    UniProtKB/TrEMBL
    Q4VBP1
    Conserved Domains (2) summary
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
    cl21561
    Location:132347
    7tm_4; Olfactory receptor
  6. XM_047438601.1XP_047294557.1  gastric inhibitory polypeptide receptor isoform X5

  7. XM_011526716.3XP_011525018.1  gastric inhibitory polypeptide receptor isoform X7

    Conserved Domains (2) summary
    smart00008
    Location:57126
    HormR; Domain present in hormone receptors
    cl21561
    Location:134265
    7tm_4; Olfactory receptor
  8. XM_047438602.1XP_047294558.1  gastric inhibitory polypeptide receptor isoform X8

  9. XM_047438603.1XP_047294559.1  gastric inhibitory polypeptide receptor isoform X9

    UniProtKB/TrEMBL
    K7EPD9
    Related
    ENSP00000467342.1, ENST00000585889.1
  10. XM_011526715.3XP_011525017.1  gastric inhibitory polypeptide receptor isoform X6

    See identical proteins and their annotated locations for XP_011525017.1

    UniProtKB/TrEMBL
    A0A494C077
    Conserved Domains (1) summary
    pfam00002
    Location:1291
    7tm_2; 7 transmembrane receptor (Secretin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48495760..48511255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320524.1XP_054176499.1  gastric inhibitory polypeptide receptor isoform X3

  2. XM_054320523.1XP_054176498.1  gastric inhibitory polypeptide receptor isoform X2

  3. XM_054320521.1XP_054176496.1  gastric inhibitory polypeptide receptor isoform X1

  4. XM_054320520.1XP_054176495.1  gastric inhibitory polypeptide receptor isoform X1

  5. XM_054320525.1XP_054176500.1  gastric inhibitory polypeptide receptor isoform X4

  6. XM_054320526.1XP_054176501.1  gastric inhibitory polypeptide receptor isoform X5

  7. XM_054320528.1XP_054176503.1  gastric inhibitory polypeptide receptor isoform X7

  8. XM_054320529.1XP_054176504.1  gastric inhibitory polypeptide receptor isoform X8

  9. XM_054320530.1XP_054176505.1  gastric inhibitory polypeptide receptor isoform X9

    UniProtKB/TrEMBL
    K7EPD9
  10. XM_054320522.1XP_054176497.1  gastric inhibitory polypeptide receptor isoform X1

  11. XM_054320527.1XP_054176502.1  gastric inhibitory polypeptide receptor isoform X6