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GIPR gastric inhibitory polypeptide receptor [ Homo sapiens (human) ]

Gene ID: 2696, updated on 11-Sep-2019

Summary

Official Symbol
GIPRprovided by HGNC
Official Full Name
gastric inhibitory polypeptide receptorprovided by HGNC
Primary source
HGNC:HGNC:4271
See related
Ensembl:ENSG00000010310 MIM:137241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGQTL2
Summary
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Expression
Broad expression in stomach (RPKM 5.3), fat (RPKM 1.5) and 16 other tissues See more
Orthologs

Genomic context

See GIPR in Genome Data Viewer
Location:
19q13.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45668187..45683722)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46171490..46185717)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene EMAP like 2 Neighboring gene EML2 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 836, pseudogene Neighboring gene microRNA 642a Neighboring gene microRNA 642b Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene glutaminyl-peptide cyclotransferase like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Meta-analysis identifies common variants associated with body mass index in east Asians.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

Pathways from BioSystems

  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
    Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gastric inhibitory peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
gastric inhibitory peptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to nutrient TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gastric inhibitory polypeptide receptor
Names
GIP-R
glucose-dependent insulinotropic polypeptide receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000164.4NP_000155.1  gastric inhibitory polypeptide receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_000155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006132, AC007191, BM129443, BU784011, U39231
    Consensus CDS
    CCDS12671.1
    UniProtKB/Swiss-Prot
    P48546
    Related
    ENSP00000467494.1, ENST00000590918.6
    Conserved Domains (2) summary
    smart00008
    Location:57126
    HormR; Domain present in hormone receptors
    cd15929
    Location:134409
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_001308418.2NP_001295347.1  gastric inhibitory polypeptide receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001295347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC006132, AC007191, BC143300, BM129443, BU784011, U39231
    Consensus CDS
    CCDS82367.1
    UniProtKB/Swiss-Prot
    P48546
    Related
    ENSP00000305321.8, ENST00000304207.12
    Conserved Domains (2) summary
    pfam00002
    Location:98352
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl02422
    Location:4990
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45668187..45683722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526710.2XP_011525012.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_011525012.1

    Conserved Domains (2) summary
    pfam00002
    Location:134430
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
  2. XM_011526709.2XP_011525011.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_011525011.1

    Conserved Domains (2) summary
    pfam00002
    Location:134430
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
  3. XM_011526713.2XP_011525015.1  gastric inhibitory polypeptide receptor isoform X3

    Conserved Domains (2) summary
    pfam02793
    Location:58121
    HRM; Hormone receptor domain
    cl21561
    Location:132347
    7tm_4; Olfactory receptor
  4. XM_011526711.2XP_011525013.1  gastric inhibitory polypeptide receptor isoform X2

    Conserved Domains (1) summary
    pfam00002
    Location:98394
    7tm_2; 7 transmembrane receptor (Secretin family)
  5. XM_011526715.2XP_011525017.1  gastric inhibitory polypeptide receptor isoform X4

    See identical proteins and their annotated locations for XP_011525017.1

    Conserved Domains (1) summary
    pfam00002
    Location:1291
    7tm_2; 7 transmembrane receptor (Secretin family)
  6. XM_011526714.2XP_011525016.1  gastric inhibitory polypeptide receptor isoform X4

    See identical proteins and their annotated locations for XP_011525016.1

    Conserved Domains (1) summary
    pfam00002
    Location:1291
    7tm_2; 7 transmembrane receptor (Secretin family)
  7. XM_011526716.2XP_011525018.1  gastric inhibitory polypeptide receptor isoform X9

    Conserved Domains (2) summary
    smart00008
    Location:57126
    HormR; Domain present in hormone receptors
    cl21561
    Location:134265
    7tm_4; Olfactory receptor
  8. XM_017026584.1XP_016882073.1  gastric inhibitory polypeptide receptor isoform X5

  9. XM_017026585.1XP_016882074.1  gastric inhibitory polypeptide receptor isoform X6

  10. XM_017026587.1XP_016882076.1  gastric inhibitory polypeptide receptor isoform X8

  11. XM_017026586.1XP_016882075.1  gastric inhibitory polypeptide receptor isoform X7

RNA

  1. XR_001753655.1 RNA Sequence

  2. XR_935791.2 RNA Sequence

    Related
    ENST00000585889.1
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