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HBP1 HMG-box transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 26959, updated on 12-Aug-2018

Summary

Official Symbol
HBP1provided by HGNC
Official Full Name
HMG-box transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:23200
See related
Ensembl:ENSG00000105856 MIM:616714; Vega:OTTHUMG00000157642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 32.0), endometrium (RPKM 26.6) and 25 other tissues See more
Orthologs

Genomic context

See HBP1 in Genome Data Viewer
Location:
7q22.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (107168961..107202529)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106809406..106842974)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Neighboring gene uncharacterized LOC105375441 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16340

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
HMG box-containing protein 1
Names
high mobility group box transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244262.1NP_001231191.1  HMG box-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001231191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK295910, BC017069
    UniProtKB/Swiss-Prot
    O60381
    UniProtKB/TrEMBL
    B4DJ36
    Conserved Domains (2) summary
    smart00536
    Location:224350
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:443514
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  2. NM_012257.3NP_036389.2  HMG box-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_036389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF182038, AK025284, BC017069
    Consensus CDS
    CCDS5741.1
    UniProtKB/Swiss-Prot
    O60381
    UniProtKB/TrEMBL
    A0A024R722
    Related
    ENSP00000222574.4, OTTHUMP00000212317, ENST00000222574.8, OTTHUMT00000349297
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    107168961..107202529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011967.2XP_016867456.1  HMG box-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O60381
    UniProtKB/TrEMBL
    A0A024R722
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  2. XM_024446714.1XP_024302482.1  HMG box-containing protein 1 isoform X1

    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  3. XM_005250266.3XP_005250323.1  HMG box-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250323.1

    UniProtKB/Swiss-Prot
    O60381
    UniProtKB/TrEMBL
    A0A024R722
    Related
    ENSP00000418738.1, OTTHUMP00000212319, ENST00000485846.5
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  4. XM_005250267.3XP_005250324.1  HMG box-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250324.1

    UniProtKB/Swiss-Prot
    O60381
    UniProtKB/TrEMBL
    A0A024R722
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  5. XM_024446713.1XP_024302481.1  HMG box-containing protein 1 isoform X1

    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:433504
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RNA

  1. XR_002956419.1 RNA Sequence

  2. XR_001744628.1 RNA Sequence

  3. XR_002956420.1 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p12 PATCHES

    Range
    14483..48051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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