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COPG2 COPI coat complex subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 26958, updated on 23-Nov-2021

Summary

Official Symbol
COPG2provided by HGNC
Official Full Name
COPI coat complex subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:2237
See related
Ensembl:ENSG00000158623 MIM:604355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2-COP; gamma-2-COP
Expression
Ubiquitous expression in testis (RPKM 19.0), ovary (RPKM 19.0) and 25 other tissues See more
Orthologs
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Genomic context

See COPG2 in Genome Data Viewer
Location:
7q32.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130506238..130668748, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (130146079..130353588, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MEST intronic transcript 1, antisense RNA Neighboring gene mesoderm specific transcript Neighboring gene microRNA 335 Neighboring gene COPG2 imprinted transcript 1 Neighboring gene RNA, 5S ribosomal pseudogene 246 Neighboring gene testis specific 13 Neighboring gene uncharacterized LOC105375508 Neighboring gene Kruppel like factor 14 Neighboring gene uncharacterized LOC105375509 Neighboring gene armadillo repeat containing X-linked 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11781, DKFZp761N09121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
coatomer subunit gamma-2
Names
coat protein, nonclathrin, gamma-2-cop
coatomer protein complex subunit gamma 2
gamma-2-coat protein
testicular secretory protein Li 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290033.2NP_001276962.1  coatomer subunit gamma-2 isoform 2

    See identical proteins and their annotated locations for NP_001276962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162012, BC110796, BX353590
    Consensus CDS
    CCDS78275.1
    UniProtKB/Swiss-Prot
    Q9UBF2
    UniProtKB/TrEMBL
    Q9NSM7
    Related
    ENSP00000331218.8, ENST00000330992.8
    Conserved Domains (2) summary
    COG5240
    Location:7718
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    sd00044
    Location:398423
    HEAT; HEAT repeat [structural motif]
  2. NM_012133.6NP_036265.3  coatomer subunit gamma-2 isoform 1

    See identical proteins and their annotated locations for NP_036265.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF157833, AK291409, BX089636, HY355769
    Consensus CDS
    CCDS75662.1
    UniProtKB/Swiss-Prot
    Q9UBF2
    UniProtKB/TrEMBL
    A0A140VK12
    Related
    ENSP00000402346.2, ENST00000425248.5
    Conserved Domains (2) summary
    COG5240
    Location:7866
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    sd00044
    Location:398423
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130506238..130668748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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