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RANBP6 RAN binding protein 6 [ Homo sapiens (human) ]

Gene ID: 26953, updated on 21-Oct-2018

Summary

Official Symbol
RANBP6provided by HGNC
Official Full Name
RAN binding protein 6provided by HGNC
Primary source
HGNC:HGNC:9851
See related
Ensembl:ENSG00000137040 Vega:OTTHUMG00000019512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 13.1), brain (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See RANBP6 in Genome Data Viewer
Location:
9p24.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (6011019..6015660, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6011019..6015640, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene KIAA2026 Neighboring gene melan-A Neighboring gene microRNA 4665 Neighboring gene uncharacterized LOC107987046 Neighboring gene general transcription factor IIIA pseudogene 1 Neighboring gene interleukin 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with RAN binding protein 6 (RANBP6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ54311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ran-binding protein 6
Names
Ran-GTP binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243202.1NP_001230131.1  ran-binding protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI568841, BC012805, DA116213, DA155272, DA234653, DC334669
    UniProtKB/Swiss-Prot
    O60518
    Conserved Domains (3) summary
    pfam13513
    Location:575635
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:21123
    HEAT_2; HEAT repeats
    sd00044
    Location:521546
    HEAT; HEAT repeat [structural motif]
  2. NM_001243203.1NP_001230132.1  ran-binding protein 6 isoform 3

    See identical proteins and their annotated locations for NP_001230132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI568841, AK300408, BC012805, DC334669
    Consensus CDS
    CCDS78378.1
    UniProtKB/Swiss-Prot
    O60518
    UniProtKB/TrEMBL
    A0A096LNS2, B4DTX6
    Related
    ENSP00000485188.1, OTTHUMP00000278003, ENST00000485372.1, OTTHUMT00000051651
  3. NM_012416.3NP_036548.1  ran-binding protein 6 isoform 1

    See identical proteins and their annotated locations for NP_036548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI568841, AK001982, BC098406, DC334669
    Consensus CDS
    CCDS6467.1
    UniProtKB/Swiss-Prot
    O60518
    Related
    ENSP00000259569.5, OTTHUMP00000021039, ENST00000259569.5, OTTHUMT00000051650
    Conserved Domains (2) summary
    COG5215
    Location:309640
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:330353
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    6011019..6015660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014624.1XP_016870113.1  ran-binding protein 6 isoform X1

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