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Trpc7 transient receptor potential cation channel, subfamily C, member 7 [ Mus musculus (house mouse) ]

Gene ID: 26946, updated on 9-Sep-2018

Summary

Official Symbol
Trpc7provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 7provided by MGI
Primary source
MGI:MGI:1349470
See related
Ensembl:ENSMUSG00000021541 Vega:OTTMUSG00000024552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRP7; Trrp8
Summary
The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in CNS E18 (RPKM 2.1), frontal lobe adult (RPKM 1.3) and 6 other tissues See more
Orthologs

Genomic context

See Trpc7 in Genome Data Viewer
Location:
13; 13 B1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (56773098..56895980, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (56874469..56996949, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33019 Neighboring gene SMAD family member 5 Neighboring gene predicted gene, 40962 Neighboring gene predicted gene, 33140

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
manganese ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
short transient receptor potential channel 7
Names
transient receptor potential protein homologue TRP7
transient receptor protein 7
transient receptor protein 8
NP_001289301.1
NP_001289302.1
NP_036165.1
XP_006517325.1
XP_006517326.1
XP_006517327.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302372.1NP_001289301.1  short transient receptor potential channel 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC132322, AC132886, AK135153, AK137418
    Consensus CDS
    CCDS79192.1
    UniProtKB/TrEMBL
    E9PVJ9, Q3UXW9
    Related
    ENSMUSP00000105497.1, OTTMUSP00000029407, ENSMUST00000109871.7, OTTMUST00000060303
    Conserved Domains (5) summary
    cd00204
    Location:51184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27821
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:582665
    FTSW_RODA_SPOVE; Cell cycle protein
  2. NM_001302373.1NP_001289302.1  short transient receptor potential channel 7 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC132886, AK135153, AK137418
    UniProtKB/TrEMBL
    Q3UXW9
    Conserved Domains (2) summary
    pfam00520
    Location:52299
    Ion_trans; Ion transport protein
    cl00511
    Location:197280
    FTSW_RODA_SPOVE; Cell cycle protein
  3. NM_012035.3NP_036165.1  short transient receptor potential channel 7 isoform 1

    See identical proteins and their annotated locations for NP_036165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC132322, AC132886, AK135153, AK137418
    Consensus CDS
    CCDS26566.1
    UniProtKB/Swiss-Prot
    Q9WVC5
    UniProtKB/TrEMBL
    Q0VFY2, Q3UXW9
    Related
    ENSMUSP00000022023.6, OTTMUSP00000029406, ENSMUST00000022023.12, OTTMUST00000060302
    Conserved Domains (5) summary
    cd00204
    Location:51184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27822
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:582665
    FTSW_RODA_SPOVE; Cell cycle protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    56773098..56895980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517263.3XP_006517326.1  short transient receptor potential channel 7 isoform X2

    Related
    ENSMUSP00000133411.1, OTTMUSP00000054085, ENSMUST00000173817.8, OTTMUST00000096743
    Conserved Domains (5) summary
    cd00204
    Location:150283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:126860
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:297355
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:176207
    ANK; ANK repeat [structural motif]
    cl00511
    Location:620703
    FTSW_RODA_SPOVE; Cell cycle protein
  2. XM_006517264.3XP_006517327.1  short transient receptor potential channel 7 isoform X3

    Related
    ENSMUSP00000134662.2, OTTMUSP00000054086, ENSMUST00000173513.8, OTTMUST00000096744
    Conserved Domains (5) summary
    cd00204
    Location:150283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:126805
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:297355
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:176207
    ANK; ANK repeat [structural motif]
    cl00511
    Location:565648
    FTSW_RODA_SPOVE; Cell cycle protein
  3. XM_006517262.3XP_006517325.1  short transient receptor potential channel 7 isoform X1

    Related
    ENSMUSP00000133305.1, OTTMUSP00000054083, ENSMUST00000174457.8, OTTMUST00000096741
    Conserved Domains (5) summary
    cd00204
    Location:150283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:126866
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:297355
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:176207
    ANK; ANK repeat [structural motif]
    cl00511
    Location:626709
    FTSW_RODA_SPOVE; Cell cycle protein

RNA

  1. XR_001780787.1 RNA Sequence

    Related
    ENSMUST00000151918.7, OTTMUST00000060304
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