U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polr3e polymerase (RNA) III (DNA directed) polypeptide E [ Mus musculus (house mouse) ]

Gene ID: 26939, updated on 8-Dec-2022

Summary

Official Symbol
Polr3eprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Eprovided by MGI
Primary source
MGI:MGI:1349452
See related
Ensembl:ENSMUSG00000030880 AllianceGenome:MGI:1349452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sin; RPC5
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription, DNA-templated. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 10.6), limb E14.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Polr3e in Genome Data Viewer
Location:
7; 7 F2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120516960..120546658)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120917778..120947435)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor-2 kinase Neighboring gene predicted gene 15774 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene cerebellar degeneration-related 2 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene predicted pseudogene 9234

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC5
Names
RNA polymerase III polypeptide E
RNA polymerase III subunit 5
RNA polymerase III subunit C5
sex-lethal interactor homolog
sxl interactor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164096.2NP_001157568.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

    See identical proteins and their annotated locations for NP_001157568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC122248
    Consensus CDS
    CCDS52383.1
    UniProtKB/Swiss-Prot
    Q9CZT4
    Related
    ENSMUSP00000146970.2, ENSMUST00000207481.2
    Conserved Domains (1) summary
    pfam04801
    Location:5406
    Sin_N; Sin-like protein conserved region
  2. NM_001379288.1NP_001366217.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC122248
    Conserved Domains (1) summary
    pfam04801
    Location:5436
    Sin_N; Sin-like protein conserved region
  3. NM_025298.4NP_079574.2  DNA-directed RNA polymerase III subunit RPC5 isoform 1

    See identical proteins and their annotated locations for NP_079574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122248
    Consensus CDS
    CCDS21797.1
    UniProtKB/Swiss-Prot
    Q9CZT4, Q9DBD1
    UniProtKB/TrEMBL
    Q3TWE8
    Related
    ENSMUSP00000033173.8, ENSMUST00000033173.15
    Conserved Domains (1) summary
    pfam04801
    Location:5432
    Sin_N; Sin-like protein conserved region

RNA

  1. NR_166590.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122248
  2. NR_166591.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122248

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120516960..120546658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322284.3XP_017177773.1  DNA-directed RNA polymerase III subunit RPC5 isoform X1

    Conserved Domains (1) summary
    pfam04801
    Location:5431
    Sin_N; Sin-like protein conserved region
  2. XM_036153139.1XP_036009032.1  DNA-directed RNA polymerase III subunit RPC5 isoform X3

    Conserved Domains (1) summary
    pfam04801
    Location:1396
    Sin_N; Sin-like protein conserved region
  3. XM_006507887.4XP_006507950.1  DNA-directed RNA polymerase III subunit RPC5 isoform X4

    Conserved Domains (1) summary
    pfam04801
    Location:7321
    Sin_N; Sin-like protein conserved region
  4. XM_036153138.1XP_036009031.1  DNA-directed RNA polymerase III subunit RPC5 isoform X2

    Conserved Domains (1) summary
    pfam04801
    Location:1400
    Sin_N; Sin-like protein conserved region

RNA

  1. XR_004934106.1 RNA Sequence

  2. XR_004934107.1 RNA Sequence

  3. XR_004934105.1 RNA Sequence

  4. XR_001785562.3 RNA Sequence