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Tox2 TOX high mobility group box family member 2 [ Mus musculus (house mouse) ]

Gene ID: 269389, updated on 10-Dec-2022

Summary

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Official Symbol
Tox2provided by MGI
Official Full Name
TOX high mobility group box family member 2provided by MGI
Primary source
MGI:MGI:3611233
See related
Ensembl:ENSMUSG00000074607 AllianceGenome:MGI:3611233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcx1; RxHMG1
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; notochord; and retina. Orthologous to human TOX2 (TOX high mobility group box family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 36.7), mammary gland adult (RPKM 15.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Tox2 in Genome Data Viewer
Location:
2 H3; 2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163044978..163166092)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163203058..163324172)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 11454 Neighboring gene VISTA enhancer mm1561 Neighboring gene VISTA enhancer mm1646 Neighboring gene junctophilin 2 Neighboring gene predicted gene, 35750 Neighboring gene oxidative stress responsive serine rich 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility. Xu W, et al. Immunity, 2019 Nov 19. PMID 31732165
  2. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion. Seo H, et al. Proc Natl Acad Sci U S A, 2019 Jun 18. PMID 31152140, Free PMC Article
  3. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Liang S, et al. Mol Vis, 2004 Oct 8. PMID 15496829
  4. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Kajitani T, et al. Endocrinology, 2004 May. PMID 14764631
  5. The single-cell transcriptional landscape of mammalian organogenesis. Cao J, et al. Nature, 2019 Feb. PMID 30787437, Free PMC Article

See all (13) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tox2(-/-) mice exhibited defective Tfh differentiation, and inhibition of both Tox2 and the related transcription factor Tox abolished Tfh differentiation. Thus, a Tox2-Bcl6 axis establishes a transcriptional feed-forward loop that promotes the Tfh program.
    Title: The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.
  2. Identification and functional analysis of the rat Gcx1 ortholog.
    Title: Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TOX high mobility group box family member 2
Names
granulosa cell HMG-box protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098799.3 → NP_001092269.1  TOX high mobility group box family member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL589876
    Consensus CDS
    CCDS50790.1
    UniProtKB/TrEMBL
    E9Q0B9
    Related
    ENSMUSP00000126243.2, ENSMUST00000165937.8
    Conserved Domains (1) summary
    cd00084
    Location:253 → 318
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  2. NM_001363063.2 → NP_001349992.1  TOX high mobility group box family member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    UniProtKB/TrEMBL
    A0A6P7QMF3
    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  3. NM_001363064.2 → NP_001349993.1  TOX high mobility group box family member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589876
    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  4. NM_001372575.1 → NP_001359504.1  TOX high mobility group box family member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    Conserved Domains (1) summary
    cd00084
    Location:246 → 311
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  5. NM_001372576.1 → NP_001359505.1  TOX high mobility group box family member 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    Consensus CDS
    CCDS89577.1
    UniProtKB/TrEMBL
    A2A473
    Related
    ENSMUSP00000105055.3, ENSMUST00000109428.9
    Conserved Domains (1) summary
    cd00084
    Location:246 → 311
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  6. NM_001372577.1 → NP_001359506.1  TOX high mobility group box family member 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL589876
    Related
    ENSMUSP00000096710.4, ENSMUST00000099110.10
    Conserved Domains (1) summary
    cd00084
    Location:253 → 318
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  7. NM_001372578.2 → NP_001359507.1  TOX high mobility group box family member 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (7).
    Source sequence(s)
    AL589874, AL589876
    Conserved Domains (1) summary
    cd00084
    Location:272 → 337
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  8. NM_001372579.1 → NP_001359508.1  TOX high mobility group box family member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  9. NM_001372580.2 → NP_001359509.1  TOX high mobility group box family member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  10. NM_001407351.1 → NP_001394280.1  TOX high mobility group box family member 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876

  11. NM_001407352.1 → NP_001394281.1  TOX high mobility group box family member 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876

  12. NM_001407353.1 → NP_001394282.1  TOX high mobility group box family member 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876

  13. NM_001407354.1 → NP_001394283.1  TOX high mobility group box family member 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876

  14. NM_001407355.1 → NP_001394284.1  TOX high mobility group box family member 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876

  15. NM_001407356.1 → NP_001394285.1  TOX high mobility group box family member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589876
    UniProtKB/TrEMBL
    A0A6P7QMF3

  16. NM_001407357.1 → NP_001394286.1  TOX high mobility group box family member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589874, AL589876
    UniProtKB/TrEMBL
    A0A6P7QMF3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163044978..163166092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162246.1 → XP_036018139.1  TOX high mobility group box family member 2 isoform X3

    Conserved Domains (1) summary
    cd00084
    Location:250 → 315
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  2. XM_006499610.5 → XP_006499673.1  TOX high mobility group box family member 2 isoform X2

    Conserved Domains (1) summary
    cd00084
    Location:250 → 315
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  3. XM_030251667.2 → XP_030107527.1  TOX high mobility group box family member 2 isoform X4

    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  4. XM_036162245.1 → XP_036018138.1  TOX high mobility group box family member 2 isoform X1

    Conserved Domains (1) summary
    cd00084
    Location:272 → 337
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  5. XM_006499615.5 → XP_006499678.1  TOX high mobility group box family member 2 isoform X4

    Conserved Domains (1) summary
    cd00084
    Location:204 → 269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Nucleotide Protein Strain
Heading Accession and Version

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