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Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon [ Mus musculus (house mouse) ]

Gene ID: 26932, updated on 18-Jun-2024

Summary

Official Symbol
Ppp2r5eprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B', epsilonprovided by MGI
Primary source
MGI:MGI:1349473
See related
Ensembl:ENSMUSG00000021051 AllianceGenome:MGI:1349473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B56beta; 4633401M22Rik
Summary
Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; gonad; and thymus. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.3), CNS E11.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp2r5e in Genome Data Viewer
Location:
12 C3; 12 32.75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (75496237..75643064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (75449463..75596237, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member J Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene STARR-seq mESC enhancer starr_32491 Neighboring gene predicted gene, 34613 Neighboring gene glycoprotein hormone beta 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76550614-76550799 Neighboring gene STARR-seq mESC enhancer starr_32492 Neighboring gene STARR-seq mESC enhancer starr_32494 Neighboring gene STARR-seq mESC enhancer starr_32495 Neighboring gene STARR-positive B cell enhancer ABC_E2388 Neighboring gene predicted gene, 34666 Neighboring gene ribosomal protein lateral stalk subunit P2, pseudogene 1 Neighboring gene WD repeat domain 89

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 4633401M22Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Names
protein phosphatase 2A subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012024.3NP_036154.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

    See identical proteins and their annotated locations for NP_036154.1

    Status: VALIDATED

    Source sequence(s)
    AC124414, AK132432
    Consensus CDS
    CCDS25983.1
    UniProtKB/Swiss-Prot
    Q3V1I5, Q571M6, Q61151, Q8C2M2
    Related
    ENSMUSP00000021447.8, ENSMUST00000021447.9
    Conserved Domains (2) summary
    pfam01603
    Location:55435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    75496237..75643064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515926.4XP_006515989.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2

    See identical proteins and their annotated locations for XP_006515989.1

    Conserved Domains (2) summary
    pfam01603
    Location:55430
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  2. XM_006515925.4XP_006515988.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1

    See identical proteins and their annotated locations for XP_006515988.1

    UniProtKB/Swiss-Prot
    Q3V1I5, Q571M6, Q61151, Q8C2M2
    Conserved Domains (2) summary
    pfam01603
    Location:55435
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    cl27532
    Location:267
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
  3. XM_006515927.5XP_006515990.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3

    Conserved Domains (1) summary
    pfam01603
    Location:30410
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)