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Foxl2 forkhead box L2 [ Mus musculus (house mouse) ]

Gene ID: 26927, updated on 31-Jan-2023

Summary

Official Symbol
Foxl2provided by MGI
Official Full Name
forkhead box L2provided by MGI
Primary source
MGI:MGI:1349428
See related
Ensembl:ENSMUSG00000050397 AllianceGenome:MGI:1349428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BPES; Pfrk; PINTO
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including adenohypophysis; branchial arch; eye; future pituitary; and genitourinary system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Foxl2 in Genome Data Viewer
Location:
9; 9 E3.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98837660..98840179)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98955607..98958126)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene forkhead box L2, opposite strand Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene predicted gene 1123

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase regulator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extraocular skeletal muscle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within female somatic sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within granulosa cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of follicle-stimulating hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of luteinizing hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within uterus development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
forkhead box protein L2
Names
P-Frk
pituitary forkhead factor
putative transcription factor foxl2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012020.2NP_036150.1  forkhead box protein L2

    See identical proteins and their annotated locations for NP_036150.1

    Status: VALIDATED

    Source sequence(s)
    AC120148, BC137812
    Consensus CDS
    CCDS23430.1
    UniProtKB/Swiss-Prot
    O88470, Q8K3X9
    UniProtKB/TrEMBL
    Q2TVT7
    Related
    ENSMUSP00000053297.3, ENSMUST00000051312.5
    Conserved Domains (1) summary
    smart00339
    Location:50138
    FH; FORKHEAD

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    98837660..98840179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)