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Gtf3c4 general transcription factor IIIC, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 269252, updated on 5-Mar-2024

Summary

Official Symbol
Gtf3c4provided by MGI
Official Full Name
general transcription factor IIIC, polypeptide 4provided by MGI
Primary source
MGI:MGI:2138937
See related
Ensembl:ENSMUSG00000035666 AllianceGenome:MGI:2138937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAT12; TFIIIC90; 5330400C03
Summary
Predicted to enable DNA binding activity and histone acetyltransferase activity. Predicted to be involved in transcription initiation from RNA polymerase III promoter. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in limb. Orthologous to human GTF3C4 (general transcription factor IIIC subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.3), whole brain E14.5 (RPKM 7.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 A3; 2 19.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28712311..28730628, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28822299..28840360, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene microRNA 3088 Neighboring gene STARR-seq mESC enhancer starr_04033 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene DEAD/H box helicase 31 Neighboring gene BarH like homeobox 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in transcription initiation at RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIIC complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
general transcription factor 3C polypeptide 4
Names
TF3C-delta
TFIIIC 90 kDa subunit
general transcription factor IIIC 4
transcription factor IIIC 90 kDa subunit
transcription factor IIIC subunit delta
NP_001159505.1
NP_766565.2
XP_006498141.1
XP_036018130.1
XP_036018131.1
XP_036018132.1
XP_036018133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166033.1NP_001159505.1  general transcription factor 3C polypeptide 4 isoform 2

    See identical proteins and their annotated locations for NP_001159505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift and a downstream translation start site to be used. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL732526, BC117919, BU610856, CN530016
    Consensus CDS
    CCDS50550.1
    UniProtKB/TrEMBL
    E9Q2B0, Q3UJL1
    Related
    ENSMUSP00000132171.2, ENSMUST00000171404.8
    Conserved Domains (2) summary
    pfam12660
    Location:599671
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    pfam12657
    Location:1109
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
  2. NM_172977.3NP_766565.2  general transcription factor 3C polypeptide 4 isoform 1

    See identical proteins and their annotated locations for NP_766565.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL732526, BC117919, CN530016
    Consensus CDS
    CCDS15847.1
    UniProtKB/Swiss-Prot
    Q148Y1, Q8BKZ4, Q8BMQ2
    UniProtKB/TrEMBL
    Q501L4
    Related
    ENSMUSP00000042265.6, ENSMUST00000037117.6
    Conserved Domains (2) summary
    pfam12657
    Location:61250
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
    pfam12660
    Location:740812
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28712311..28730628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162237.1XP_036018130.1  general transcription factor 3C polypeptide 4 isoform X1

    UniProtKB/TrEMBL
    Q501L4
    Conserved Domains (1) summary
    pfam12657
    Location:61250
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
  2. XM_036162239.1XP_036018132.1  general transcription factor 3C polypeptide 4 isoform X3

    UniProtKB/TrEMBL
    Q3UJL1
    Conserved Domains (1) summary
    pfam12657
    Location:1109
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
  3. XM_036162240.1XP_036018133.1  general transcription factor 3C polypeptide 4 isoform X3

    UniProtKB/TrEMBL
    Q3UJL1
    Conserved Domains (1) summary
    pfam12657
    Location:1109
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
  4. XM_006498078.5XP_006498141.1  general transcription factor 3C polypeptide 4 isoform X2

    See identical proteins and their annotated locations for XP_006498141.1

    UniProtKB/TrEMBL
    E9Q2B0, Q3UJL1
    Conserved Domains (2) summary
    pfam12660
    Location:599671
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    pfam12657
    Location:1109
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term
  5. XM_036162238.1XP_036018131.1  general transcription factor 3C polypeptide 4 isoform X2

    UniProtKB/TrEMBL
    E9Q2B0, Q3UJL1
    Conserved Domains (2) summary
    pfam12660
    Location:599671
    zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
    pfam12657
    Location:1109
    TFIIIC_delta; Transcription factor IIIC subunit delta N-term