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Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A [ Mus musculus (house mouse) ]

Gene ID: 269181, updated on 26-Sep-2022

Summary

Official Symbol
Mgat4aprovided by MGI
Official Full Name
mannoside acetylglucosaminyltransferase 4, isoenzyme Aprovided by MGI
Primary source
MGI:MGI:2662992
See related
Ensembl:ENSMUSG00000026110 AllianceGenome:MGI:2662992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GnT-IVa; glcNAc-T-IVa; 9530018I07Rik
Summary
Enables acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in Golgi apparatus; extracellular region; and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 27.4), colon adult (RPKM 23.5) and 20 other tissues See more
Orthologs
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Genomic context

See Mgat4a in Genome Data Viewer
Location:
1; 1 B
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37478421..37580599, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37439340..37541060, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog Neighboring gene G1 to S phase transition pseudogene Neighboring gene predicted gene, 39627 Neighboring gene RIKEN cDNA 4930556I23 gene Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene RIKEN cDNA 4930470B04 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Names
N-acetylglucosaminyltransferase IVa
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa
NP_001277730.1
NP_776295.1
XP_006496085.1
XP_006496087.1
XP_006496089.1
XP_011236828.1
XP_017176450.1
XP_017176453.1
XP_017176454.1
XP_017176455.1
XP_017176456.1
XP_036021327.1
XP_036021329.1
XP_036021332.1
XP_036021335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290801.1NP_001277730.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2

    See identical proteins and their annotated locations for NP_001277730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
    Consensus CDS
    CCDS69882.1
    UniProtKB/Swiss-Prot
    Q812G0
    Related
    ENSMUSP00000121181.2, ENSMUST00000154819.8
    Conserved Domains (1) summary
    pfam04666
    Location:94371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. NM_173870.3NP_776295.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

    See identical proteins and their annotated locations for NP_776295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC084390, AC140321, AK035332, AK076502, AK155724, AK163327
    Consensus CDS
    CCDS14893.1
    UniProtKB/Swiss-Prot
    Q80UI0, Q812G0
    UniProtKB/TrEMBL
    A0A8C6GIS9
    Related
    ENSMUSP00000114175.2, ENSMUST00000151952.8
    Conserved Domains (2) summary
    pfam04666
    Location:103380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287302
    PGAP4-like; putative TM2 helix [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37478421..37580599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165442.1XP_036021335.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    UniProtKB/Swiss-Prot
    Q80UI0
    UniProtKB/TrEMBL
    A0A8C6GIS9
    Conserved Domains (2) summary
    pfam04666
    Location:103380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287302
    PGAP4-like; putative TM2 helix [structural motif]
  2. XM_017320964.2XP_017176453.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  3. XM_017320966.1XP_017176455.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  4. XM_006496026.2XP_006496089.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    See identical proteins and their annotated locations for XP_006496089.1

    Conserved Domains (1) summary
    pfam04666
    Location:1135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  5. XM_017320961.2XP_017176450.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X7

    Conserved Domains (1) summary
    pfam04666
    Location:94371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  6. XM_017320965.1XP_017176454.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X8

    Conserved Domains (1) summary
    pfam04666
    Location:1135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  7. XM_017320967.1XP_017176456.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X9

    Conserved Domains (1) summary
    pfam04666
    Location:1135
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  8. XM_006496024.3XP_006496087.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X5

    Conserved Domains (1) summary
    pfam04666
    Location:103380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  9. XM_006496022.5XP_006496085.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X4

    See identical proteins and their annotated locations for XP_006496085.1

    UniProtKB/Swiss-Prot
    Q80UI0, Q812G0
    UniProtKB/TrEMBL
    A0A8C6GIS9
    Conserved Domains (2) summary
    pfam04666
    Location:103380
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:287302
    PGAP4-like; putative TM2 helix [structural motif]
  10. XM_036165436.1XP_036021329.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X2

    Conserved Domains (2) summary
    pfam04666
    Location:140417
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:324339
    PGAP4-like; putative TM2 helix [structural motif]
  11. XM_036165439.1XP_036021332.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X3

    Conserved Domains (2) summary
    pfam04666
    Location:131408
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:315330
    PGAP4-like; putative TM2 helix [structural motif]
  12. XM_036165434.1XP_036021327.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X1

    Conserved Domains (2) summary
    pfam04666
    Location:140417
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
    cd21105
    Location:324339
    PGAP4-like; putative TM2 helix [structural motif]
  13. XM_011238526.3XP_011236828.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform X6

    See identical proteins and their annotated locations for XP_011236828.1

    UniProtKB/Swiss-Prot
    Q812G0
    Conserved Domains (1) summary
    pfam04666
    Location:94371
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region