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Exo1 exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 26909, updated on 21-Jan-2020

Summary

Official Symbol
Exo1provided by MGI
Official Full Name
exonuclease 1provided by MGI
Primary source
MGI:MGI:1349427
See related
Ensembl:ENSMUSG00000039748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msa; 5730442G03Rik
Expression
Biased expression in CNS E11.5 (RPKM 5.1), liver E14 (RPKM 3.6) and 11 other tissues See more
Orthologs

Genomic context

See Exo1 in Genome Data Viewer
Location:
1 H4; 1 81.9 cM
Exon count:
15
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175880768..175911396)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (177810909..177841527)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene WD repeat domain 64 Neighboring gene U2 spliceosomal RNA Neighboring gene predicted gene, 36360 Neighboring gene predicted gene, 23805 Neighboring gene beclin 2 Neighboring gene phospholipase D family, member 5 Neighboring gene RNA binding motif protein 8A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
5'-3' exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-3' exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
PubMed 
5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA 5'-3' exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA 5'-3' exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombination ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair ISO
Inferred from Sequence Orthology
more info
 
nucleobase-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
exonuclease 1
Names
exonuclease I
mExo1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012012.4NP_036142.2  exonuclease 1

    See identical proteins and their annotated locations for NP_036142.2

    Status: VALIDATED

    Source sequence(s)
    AC122854
    Consensus CDS
    CCDS15551.1
    UniProtKB/Swiss-Prot
    Q9QZ11
    Related
    ENSMUSP00000039376.6, ENSMUST00000039725.11
    Conserved Domains (3) summary
    cd09908
    Location:213289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1206
    PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam10486
    Location:665779
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    175880768..175911396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496862.4XP_006496925.1  exonuclease 1 isoform X1

    See identical proteins and their annotated locations for XP_006496925.1

    UniProtKB/Swiss-Prot
    Q9QZ11
    Conserved Domains (3) summary
    cd09908
    Location:213289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1206
    PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam10486
    Location:665779
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. XM_030254499.1XP_030110359.1  exonuclease 1 isoform X1

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