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Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked [ Mus musculus (house mouse) ]

Gene ID: 26908, updated on 17-Nov-2020

Summary

Official Symbol
Eif2s3yprovided by MGI
Official Full Name
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linkedprovided by MGI
Primary source
MGI:MGI:1349430
See related
Ensembl:ENSMUSG00000069049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S; Spy; Tfy; Eif-2g; Eif-2gy
Expression
Broad expression in CNS E18 (RPKM 11.4), CNS E14 (RPKM 7.7) and 17 other tissues See more

Genomic context

See Eif2s3y in Genome Data Viewer
Location:
Y; Ypter
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1010562..1049136)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1010562..1049134)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) Y NC_000087.6 (347055..365037)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 5D Neighboring gene nuclear encoded rRNA 5S 1 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IEA
Inferred from Electronic Annotation
more info
 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 3, Y-linked
Names
eIF-2-gamma Y
eukaryotic translation initiation factor 2 subunit gamma, Y-linked
spermatogenesis Y
spermatogonial proliferation factor
NP_001344023.1
NP_036141.1
XP_006531673.1
XP_011246895.1
XP_030107429.1
XP_036018085.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357094.1NP_001344023.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC145392
    Conserved Domains (1) summary
    cl27768
    Location:1287
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
  2. NM_012011.2NP_036141.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1

    See identical proteins and their annotated locations for NP_036141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC145392, AI661184, AK009448, BY711372
    Consensus CDS
    CCDS30542.1
    UniProtKB/Swiss-Prot
    Q9Z0N2
    Related
    ENSMUSP00000088736.3, ENSMUST00000091197.3
    Conserved Domains (4) summary
    cd01888
    Location:42248
    eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
    PTZ00327
    Location:13466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
    cd03688
    Location:249362
    eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
    cd15490
    Location:365459
    eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    1010562..1049136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251569.2XP_030107429.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X3

  2. XM_011248593.3XP_011246895.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

    See identical proteins and their annotated locations for XP_011246895.1

    Conserved Domains (4) summary
    cd01888
    Location:42248
    eIF2_gamma; Gamma subunit of initiation factor 2 (eIF2 gamma)
    PTZ00327
    Location:13452
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
    cd03688
    Location:249362
    eIF2_gamma_II; Domain II of the gamma subunit of eukaryotic translation initiation factor 2
    cd15490
    Location:365452
    eIF2_gamma_III; Domain III of eukaryotic initiation factor eIF2 gamma
  3. XM_036162192.1XP_036018085.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X1

  4. XM_006531610.4XP_006531673.1  eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform X2

    See identical proteins and their annotated locations for XP_006531673.1

    Conserved Domains (1) summary
    cl27768
    Location:1287
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004940598.1 RNA Sequence

  2. XR_879402.4 RNA Sequence

  3. XR_004940597.1 RNA Sequence

  4. XR_004940596.1 RNA Sequence

  5. XR_003953252.1 RNA Sequence

  6. XR_001782883.2 RNA Sequence

  7. XR_001782884.2 RNA Sequence

  8. XR_001782885.2 RNA Sequence

  9. XR_001782886.2 RNA Sequence

  10. XR_388245.2 RNA Sequence

  11. XR_001782887.3 RNA Sequence

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