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Cpsf7 cleavage and polyadenylation specific factor 7 [ Mus musculus (house mouse) ]

Gene ID: 269061, updated on 27-Nov-2024

Summary

Official Symbol
Cpsf7provided by MGI
Official Full Name
cleavage and polyadenylation specific factor 7provided by MGI
Primary source
MGI:MGI:1917826
See related
Ensembl:ENSMUSG00000034820 AllianceGenome:MGI:1917826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730453I16Rik; C330017N18Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; mRNA alternative polyadenylation; and protein heterotetramerization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including blastocyst; central nervous system; early embryo; olfactory epithelium; and retina. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 30.5), whole brain E14.5 (RPKM 27.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cpsf7 in Genome Data Viewer
Location:
19 A; 19 6.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10502594..10525099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10525223..10547735)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC46982

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA alternative polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA alternative polyadenylation ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA alternative polyadenylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex IEA
Inferred from Electronic Annotation
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of mRNA cleavage factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of mRNA cleavage factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cleavage and polyadenylation specificity factor subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164272.2NP_001157744.1  cleavage and polyadenylation specificity factor subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001157744.1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    UniProtKB/Swiss-Prot
    Q8BTV2
    Conserved Domains (1) summary
    cd12644
    Location:81170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
  2. NM_001362450.2NP_001349379.1  cleavage and polyadenylation specificity factor subunit 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125093
  3. NM_172302.4NP_758506.3  cleavage and polyadenylation specificity factor subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_758506.3

    Status: VALIDATED

    Source sequence(s)
    AC125093
    Consensus CDS
    CCDS29579.1
    UniProtKB/Swiss-Prot
    Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
    Related
    ENSMUSP00000038958.4, ENSMUST00000038379.5
    Conserved Domains (2) summary
    COG0724
    Location:20231
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12644
    Location:81170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10502594..10525099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250956.2XP_030106816.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_006527117.4XP_006527180.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    See identical proteins and their annotated locations for XP_006527180.1

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_036161607.1XP_036017500.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_036161606.1XP_036017499.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_030250955.1XP_030106815.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  6. XM_006527116.5XP_006527179.1  cleavage and polyadenylation specificity factor subunit 7 isoform X1

    See identical proteins and their annotated locations for XP_006527179.1

    UniProtKB/Swiss-Prot
    Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
    Conserved Domains (2) summary
    COG0724
    Location:20231
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12644
    Location:81170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
  7. XM_030250954.1XP_030106814.1  cleavage and polyadenylation specificity factor subunit 7 isoform X2

    Conserved Domains (1) summary
    cd12644
    Location:81170
    RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
  8. XM_006527119.2XP_006527182.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    See identical proteins and their annotated locations for XP_006527182.1

    Conserved Domains (1) summary
    cl17169
    Location:23101
    RRM_SF; RNA recognition motif (RRM) superfamily
  9. XM_030250958.1XP_030106818.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

  10. XM_036161608.1XP_036017501.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5