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Dagla diacylglycerol lipase, alpha [ Mus musculus (house mouse) ]

Gene ID: 269060, updated on 5-Jan-2023

Summary

Official Symbol
Daglaprovided by MGI
Official Full Name
diacylglycerol lipase, alphaprovided by MGI
Primary source
MGI:MGI:2677061
See related
Ensembl:ENSMUSG00000035735 AllianceGenome:MGI:2677061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nsddr
Summary
Enables hydrolase activity. Involved in G protein-coupled glutamate receptor signaling pathway; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within several processes, including arachidonic acid metabolic process; endocannabinoid signaling pathway; and neurotransmitter biosynthetic process. Located in dendritic spine membrane; postsynaptic membrane; and varicosity. Is integral component of postsynaptic membrane. Is expressed in brain and olfactory epithelium. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 16.8), cerebellum adult (RPKM 13.6) and 22 other tissues See more
Orthologs
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Genomic context

See Dagla in Genome Data Viewer
Location:
19; 19 A
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10222629..10282323, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10245265..10304877, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 258 Neighboring gene flap structure specific endonuclease 1 Neighboring gene myelin regulatory factor Neighboring gene predicted gene, 30042 Neighboring gene predicted gene, 30263 Neighboring gene synaptotagmin VII

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • KIAA0659

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in diacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diacylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in varicosity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
diacylglycerol lipase-alpha
Names
DAGL-alpha
DGL-alpha
neural stem cell-derived dendrite regulator
sn1-specific diacylglycerol lipase alpha
NP_932782.2
XP_017173702.1
XP_036017498.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198114.2NP_932782.2  diacylglycerol lipase-alpha

    See identical proteins and their annotated locations for NP_932782.2

    Status: VALIDATED

    Source sequence(s)
    AK147384, BC112414, BP765314, CF539357, CJ127451
    Consensus CDS
    CCDS29574.1
    UniProtKB/Swiss-Prot
    Q6WQJ1, Q6ZQ76
    UniProtKB/TrEMBL
    A0A8C6I7U9, A4FU75
    Related
    ENSMUSP00000046358.5, ENSMUST00000039327.11
    Conserved Domains (1) summary
    cd00519
    Location:288529
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10222629..10282323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161605.1XP_036017498.1  diacylglycerol lipase-alpha isoform X1

    UniProtKB/Swiss-Prot
    Q6ZQ76
    UniProtKB/TrEMBL
    A0A8C6I7U9
    Conserved Domains (1) summary
    cd00519
    Location:288529
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
  2. XM_017318213.2XP_017173702.1  diacylglycerol lipase-alpha isoform X1

    UniProtKB/Swiss-Prot
    Q6WQJ1, Q6ZQ76
    UniProtKB/TrEMBL
    A0A8C6I7U9
    Conserved Domains (1) summary
    cd00519
    Location:288529
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...