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Cenph centromere protein H [ Mus musculus (house mouse) ]

Gene ID: 26886, updated on 26-Sep-2022

Summary

Official Symbol
Cenphprovided by MGI
Official Full Name
centromere protein Hprovided by MGI
Primary source
MGI:MGI:1349448
See related
Ensembl:ENSMUSG00000045273 AllianceGenome:MGI:1349448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ENP; CENP-H; 1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik
Summary
Enables kinetochore binding activity. Predicted to be involved in chromosome segregation and mitotic spindle organization. Predicted to act upstream of or within mitotic cell cycle. Located in kinetochore and nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; hemolymphoid system gland; and skin. Orthologous to human CENPH (centromere protein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 15.8), CNS E11.5 (RPKM 12.8) and 9 other tissues See more
Orthologs
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Genomic context

See Cenph in Genome Data Viewer
Location:
13 53.23 cM; 13 D1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100896182..100912415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100759674..100775903, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin-dependent kinase 7 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene cyclin B1 Neighboring gene solute carrier family 30 (zinc transporter), member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinetochore binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in kinetochore organization TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centromere protein H
Names
centromere autoantigen H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399528.1NP_001386457.1  centromere protein H isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112701
    Conserved Domains (1) summary
    PHA02562
    Location:26155
    46; endonuclease subunit; Provisional
  2. NM_021886.3NP_068686.1  centromere protein H isoform 1

    See identical proteins and their annotated locations for NP_068686.1

    Status: VALIDATED

    Source sequence(s)
    AC112701
    Consensus CDS
    CCDS26738.1
    UniProtKB/Swiss-Prot
    Q9D0N1, Q9QYM8
    Related
    ENSMUSP00000074988.4, ENSMUST00000075550.4
    Conserved Domains (1) summary
    pfam05837
    Location:134233
    CENP-H; Centromere protein H (CENP-H)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100896182..100912415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247278.2XP_030103138.1  centromere protein H isoform X1

    Conserved Domains (2) summary
    PHA02562
    Location:26113
    46; endonuclease subunit; Provisional
    pfam05837
    Location:136157
    CENP-H; Centromere protein H (CENP-H)
  2. XM_030247279.2XP_030103139.1  centromere protein H isoform X2

    Conserved Domains (1) summary
    PHA02562
    Location:26155
    46; endonuclease subunit; Provisional
  3. XM_030247280.1XP_030103140.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33142
    CENP-H; Centromere protein H (CENP-H)
  4. XM_006517678.4XP_006517741.1  centromere protein H isoform X3

    See identical proteins and their annotated locations for XP_006517741.1

    Conserved Domains (1) summary
    pfam05837
    Location:33142
    CENP-H; Centromere protein H (CENP-H)
  5. XM_036158055.1XP_036013948.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33142
    CENP-H; Centromere protein H (CENP-H)
  6. XM_036158056.1XP_036013949.1  centromere protein H isoform X3

    Conserved Domains (1) summary
    pfam05837
    Location:33142
    CENP-H; Centromere protein H (CENP-H)

RNA

  1. XR_003950454.2 RNA Sequence