B3galt2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B3galt2provided by MGI
Official Full Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2provided by MGI
Primary source: MGI:MGI:1349461
See related: Ensembl:ENSMUSG00000033849 AllianceGenome:MGI:1349461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; male reproductive gland or organ; respiratory system; and sensory organ. Orthologous to human B3GALT2 (beta-1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 7.4), genital fat pad adult (RPKM 6.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (143516435..143525675)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (143640697..143649937)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of the genetic knockout of the beta-1,3-galactosyltransferase 2 on spatial learning and neurons in the adult mouse hippocampus and somatosensory cortex.
Title: Effects of the genetic knockout of the β-1,3-galactosyltransferase 2 on spatial learning and neurons in the adult mouse hippocampus and somatosensory cortex.
beta-1, 3-galactosyltransferase 2 deficiency exacerbates brain injury after transient focal cerebral ischemia in mice.
Title: β-1, 3-galactosyltransferase 2 deficiency exacerbates brain injury after transient focal cerebral ischemia in mice.
beta-1, 3-galactosyltransferase 2 ameliorates focal ischemic cerebral injury by maintaining blood-brain barrier integrity.
Title: β-1, 3-galactosyltransferase 2 ameliorates focal ischemic cerebral injury by maintaining blood-brain barrier integrity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142465 (e-PCR)
- UniSTS:231712

UniSTS:495935 (e-PCR)
- UniSTS:495935

B3galt2 (e-PCR), detects polymorphism
- UniSTS:495935

B3galt2 (e-PCR), detects polymorphism
- UniSTS:546677

B3galt2 (e-PCR), detects polymorphism
- UniSTS:546550

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in galactosylceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in galactosylceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-galactosyltransferase 2

Names: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase-II; beta-1,3-GalTase 2; beta3Gal-T2; beta3GalT2

NP_064409.3

EC 2.4.1.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.