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Pclo piccolo (presynaptic cytomatrix protein) [ Mus musculus (house mouse) ]

Gene ID: 26875, updated on 12-Aug-2019

Summary

Official Symbol
Pcloprovided by MGI
Official Full Name
piccolo (presynaptic cytomatrix protein)provided by MGI
Primary source
MGI:MGI:1349390
See related
Ensembl:ENSMUSG00000061601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acz; Pico
Expression
Biased expression in cerebellum adult (RPKM 10.3), cortex adult (RPKM 8.0) and 5 other tissues See more
Orthologs

Genomic context

See Pclo in Genome Data Viewer
Location:
5; 5 A1
Exon count:
25
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (14514906..14863465)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (14514918..14863459)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene DND microRNA-mediated repression inhibitor 1, pseudogene Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene uncharacterized LOC115490167 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 4e Neighboring gene predicted gene 9758

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0559

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
profilin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
structural constituent of presynaptic active zone IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
presynapse to nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic active zone assembly ISO
Inferred from Sequence Orthology
more info
 
protein localization to synapse IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
synapse organization ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle clustering IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle targeting NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cone cell pedicle ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton of presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
 
ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
rod spherule ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein piccolo
Names
aczonin
brain-derived HLMN protein
multidomain presynaptic cytomatrix protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110796.2NP_001104266.1  protein piccolo isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125043, AC125533, AC144625
    Consensus CDS
    CCDS59667.1
    UniProtKB/Swiss-Prot
    Q9QYX7
    Related
    ENSMUSP00000138419.1, ENSMUST00000182407.7
    Conserved Domains (8) summary
    cd04031
    Location:46224754
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:44244515
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:530591
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam02389
    Location:401513
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:265375
    Jun; Jun-like transcription factor
    pfam05715
    Location:9971053
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:415475
    YppG; YppG-like protein
    pfam15822
    Location:225449
    MISS; MAPK-interacting and spindle-stabilizing protein-like
  2. NM_011995.4NP_036125.4  protein piccolo isoform 1

    See identical proteins and their annotated locations for NP_036125.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125043, AC125533, AC144480, AC144625, AI852499
    Consensus CDS
    CCDS51415.1
    UniProtKB/Swiss-Prot
    Q9QYX7
    Related
    ENSMUSP00000030691.9, ENSMUST00000030691.16
    Conserved Domains (9) summary
    cd04031
    Location:46224754
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:44244515
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:530591
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam00168
    Location:49515060
    C2; C2 domain
    pfam02389
    Location:401513
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:265375
    Jun; Jun-like transcription factor
    pfam05715
    Location:9971053
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:415475
    YppG; YppG-like protein
    pfam15822
    Location:225449
    MISS; MAPK-interacting and spindle-stabilizing protein-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    14514906..14863465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503582.3XP_006503645.2  protein piccolo isoform X1

    Conserved Domains (9) summary
    cd04031
    Location:46534785
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:44554546
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:548609
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam02389
    Location:419531
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:283393
    Jun; Jun-like transcription factor
    pfam05715
    Location:10151071
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:433493
    YppG; YppG-like protein
    pfam15822
    Location:243467
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl14603
    Location:49665091
    C2; C2 domain
  2. XM_006503584.3XP_006503647.2  protein piccolo isoform X3

    Conserved Domains (9) summary
    cd04031
    Location:44944626
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:42964387
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:548609
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam02389
    Location:419531
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:283393
    Jun; Jun-like transcription factor
    pfam05715
    Location:10151071
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:433493
    YppG; YppG-like protein
    pfam15822
    Location:243467
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl14603
    Location:48074932
    C2; C2 domain
  3. XM_006503583.3XP_006503646.2  protein piccolo isoform X2

    Conserved Domains (9) summary
    cd04031
    Location:46404772
    C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
    cd00992
    Location:44424533
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:548609
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam02389
    Location:419531
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:283393
    Jun; Jun-like transcription factor
    pfam05715
    Location:10151071
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:433493
    YppG; YppG-like protein
    pfam15822
    Location:243467
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    cl14603
    Location:49535078
    C2; C2 domain
  4. XM_006503586.3XP_006503649.2  protein piccolo isoform X4

    Conserved Domains (7) summary
    cd00992
    Location:44554543
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15774
    Location:548609
    FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
    pfam02389
    Location:419531
    Cornifin; Cornifin (SPRR) family
    pfam03957
    Location:283393
    Jun; Jun-like transcription factor
    pfam05715
    Location:10151071
    zf-piccolo; Piccolo Zn-finger
    pfam14179
    Location:433493
    YppG; YppG-like protein
    pfam15822
    Location:243467
    MISS; MAPK-interacting and spindle-stabilizing protein-like

RNA

  1. XR_003955649.1 RNA Sequence

    Related
    ENSMUST00000182426.2
  2. XR_003955647.1 RNA Sequence

  3. XR_003955650.1 RNA Sequence

  4. XR_003955648.1 RNA Sequence

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