U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf31 ring finger protein 31 [ Mus musculus (house mouse) ]

Gene ID: 268749, updated on 7-Feb-2023

Summary

Official Symbol
Rnf31provided by MGI
Official Full Name
ring finger protein 31provided by MGI
Primary source
MGI:MGI:1934704
See related
Ensembl:ENSMUSG00000047098 AllianceGenome:MGI:1934704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOIP; Paul; Flj10111; mFLJ00217
Summary
Predicted to enable several functions, including linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in CD40 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; and protein ubiquitination. Acts upstream of or within negative regulation of necroptotic process. Located in cytoplasmic side of plasma membrane and cytosol. Part of CD40 receptor complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.8), spleen adult (RPKM 23.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rnf31 in Genome Data Viewer
Location:
14; 14 C3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55829199..55841131)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55591713..55603674)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables linear polyubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of LUBAC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF31
Names
HOIL-1-interacting protein
RING-type E3 ubiquitin transferase RNF31
putative Ariadne-like ubiquitin ligase
NP_919327.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194346.3NP_919327.2  E3 ubiquitin-protein ligase RNF31

    See identical proteins and their annotated locations for NP_919327.2

    Status: VALIDATED

    Source sequence(s)
    AC174678, BC057595, BY426496
    Consensus CDS
    CCDS27118.1
    UniProtKB/Swiss-Prot
    Q924T7
    Related
    ENSMUSP00000019443.9, ENSMUST00000019443.15
    Conserved Domains (6) summary
    smart00647
    Location:773835
    IBR; In Between Ring fingers
    cd14325
    Location:565619
    UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
    sd00029
    Location:348367
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam04981
    Location:693743
    NMD3; NMD3 family
    pfam16678
    Location:477621
    HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
    cl15262
    Location:51152
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55829199..55841131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)