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Tox4 TOX high mobility group box family member 4 [ Mus musculus (house mouse) ]

Gene ID: 268741, updated on 12-May-2024

Summary

Official Symbol
Tox4provided by MGI
Official Full Name
TOX high mobility group box family member 4provided by MGI
Primary source
MGI:MGI:1915389
See related
Ensembl:ENSMUSG00000016831 AllianceGenome:MGI:1915389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LCP1; A630040M18; 5730589K01Rik
Summary
Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 22.1), ovary adult (RPKM 18.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tox4 in Genome Data Viewer
Location:
14 C2; 14 26.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52516603..52532966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52279146..52295509)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene predicted gene, 26590 Neighboring gene STARR-positive B cell enhancer ABC_E5433 Neighboring gene STARR-seq mESC enhancer starr_36702 Neighboring gene RAB2B, member RAS oncogene family Neighboring gene predicted gene, 23758 Neighboring gene STARR-positive B cell enhancer ABC_E5434 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Neighboring gene spalt like transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_36704 Neighboring gene STARR-positive B cell enhancer ABC_E3112 Neighboring gene predicted gene, 53857 Neighboring gene predicted gene, 26328

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TOX high mobility group box family member 4
Names
epidermal Langerhans cell protein LCP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023434.3NP_075923.2  TOX high mobility group box family member 4

    See identical proteins and their annotated locations for NP_075923.2

    Status: VALIDATED

    Source sequence(s)
    AK137050, AK147023, AK173012, BY327085
    Consensus CDS
    CCDS36920.1
    UniProtKB/Swiss-Prot
    Q3UGN7, Q80UI2, Q8BU11, Q99PN9, Q9CS16
    UniProtKB/TrEMBL
    Q3U661
    Related
    ENSMUSP00000022766.7, ENSMUST00000022766.8
    Conserved Domains (3) summary
    PHA03160
    Location:464530
    PHA03160; hypothetical protein; Provisional
    COG5648
    Location:140306
    NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    cd00084
    Location:223288
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52516603..52532966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)