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GGT7 gamma-glutamyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 2686, updated on 25-Nov-2021

Summary

Official Symbol
GGT7provided by HGNC
Official Full Name
gamma-glutamyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4259
See related
Ensembl:ENSG00000131067 MIM:612342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGT4; GGTL3; GGTL5; D20S101
Summary
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.3), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See GGT7 in Genome Data Viewer
Location:
20q11.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (34844720..34872857, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33432523..33460659, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • dJ18C9.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hypoglycin A gamma-glutamyl transpeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutathione hydrolase 7
Names
GGT 7
gamma-glutamyltransferase 4
gamma-glutamyltransferase-like 3
gamma-glutamyltransferase-like 5
gamma-glutamyltranspeptidase 7
gamma-glutamyltranspeptidase-like 3
NP_001338631.1
NP_821158.2
XP_011527084.1
XP_011527085.1
XP_016883299.1
XP_016883300.1
XP_024307639.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351702.2NP_001338631.1  glutathione hydrolase 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a novel C-terminus and is shorter than isoform 1
    Source sequence(s)
    AL049709
    Conserved Domains (1) summary
    pfam01019
    Location:155607
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. NM_178026.3NP_821158.2  glutathione hydrolase 7 isoform 1

    See identical proteins and their annotated locations for NP_821158.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049709, BC033745, BX401449, DA117929
    Consensus CDS
    CCDS13242.2
    UniProtKB/Swiss-Prot
    Q9UJ14
    UniProtKB/TrEMBL
    A0PJJ9
    Related
    ENSP00000338964.5, ENST00000336431.10
    Conserved Domains (1) summary
    pfam01019
    Location:155654
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    34844720..34872857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451871.1XP_024307639.1  glutathione hydrolase 7 isoform X3

    Conserved Domains (1) summary
    cl19223
    Location:1420
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. XM_011528782.2XP_011527084.1  glutathione hydrolase 7 isoform X3

    Conserved Domains (1) summary
    cl19223
    Location:1420
    G_glu_transpept; Gamma-glutamyltranspeptidase
  3. XM_011528783.3XP_011527085.1  glutathione hydrolase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:1371
    G_glu_transpept; Gamma-glutamyltranspeptidase
  4. XM_017027810.2XP_016883299.1  glutathione hydrolase 7 isoform X1

  5. XM_017027811.1XP_016883300.1  glutathione hydrolase 7 isoform X2

    Conserved Domains (1) summary
    cl19223
    Location:155528
    G_glu_transpept; Gamma-glutamyltranspeptidase

RNA

  1. XR_001754243.1 RNA Sequence

  2. XR_001754242.1 RNA Sequence

  3. XR_001754241.1 RNA Sequence

  4. XR_001754240.1 RNA Sequence

  5. XR_001754244.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178025.1: Suppressed sequence

    Description
    NM_178025.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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