Format

Send to:

Choose Destination

GGT7 gamma-glutamyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 2686, updated on 6-Aug-2017
Official Symbol
GGT7provided by HGNC
Official Full Name
gamma-glutamyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:4259
See related
Ensembl:ENSG00000131067 MIM:612342; Vega:OTTHUMG00000032314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGT4; GGTL3; GGTL5; D20S101
Summary
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q11.22
Exon count:
19
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (34844720..34872858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33432523..33460661, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • dJ18C9.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hypoglycin A gamma-glutamyl transpeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
 
leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
gamma-glutamyltransferase 7
Names
GGT 7
gamma-glutamyltransferase 4
gamma-glutamyltransferase-like 3
gamma-glutamyltransferase-like 5
gamma-glutamyltranspeptidase 7
gamma-glutamyltranspeptidase-like 3
glutathione hydrolase 7
NP_821158.2
XP_011527084.1
XP_011527085.1
XP_016883298.1
XP_016883299.1
XP_016883300.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351702.1NP_001338631.1  gamma-glutamyltransferase 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a novel C-terminus and is shorter than isoform 1
    Source sequence(s)
    AL049709
  2. NM_178026.2NP_821158.2  gamma-glutamyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_821158.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049709, BC033745, BX401449, DA117929
    Consensus CDS
    CCDS13242.2
    UniProtKB/Swiss-Prot
    Q9UJ14
    UniProtKB/TrEMBL
    A0PJJ9
    Related
    ENSP00000338964.5, OTTHUMP00000030708, ENST00000336431.9, OTTHUMT00000078816
    Conserved Domains (1) summary
    pfam01019
    Location:155654
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    34844720..34872858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027809.1XP_016883298.1  gamma-glutamyltransferase 7 isoform X1

  2. XM_011528782.2XP_011527084.1  gamma-glutamyltransferase 7 isoform X4

    Conserved Domains (1) summary
    cl19223
    Location:1420
    G_glu_transpept; Gamma-glutamyltranspeptidase
  3. XM_011528783.2XP_011527085.1  gamma-glutamyltransferase 7 isoform X5

    Conserved Domains (1) summary
    cl19223
    Location:1371
    G_glu_transpept; Gamma-glutamyltranspeptidase
  4. XM_017027810.1XP_016883299.1  gamma-glutamyltransferase 7 isoform X2

  5. XM_017027811.1XP_016883300.1  gamma-glutamyltransferase 7 isoform X3

    Conserved Domains (1) summary
    cl19223
    Location:155528
    G_glu_transpept; Gamma-glutamyltranspeptidase

RNA

  1. XR_001754243.1 RNA Sequence

  2. XR_001754242.1 RNA Sequence

  3. XR_001754241.1 RNA Sequence

  4. XR_001754240.1 RNA Sequence

  5. XR_001754244.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    33333913..33362031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center