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Greb1 gene regulated by estrogen in breast cancer protein [ Mus musculus (house mouse) ]

Gene ID: 268527, updated on 2-May-2024

Summary

Official Symbol
Greb1provided by MGI
Official Full Name
gene regulated by estrogen in breast cancer proteinprovided by MGI
Primary source
MGI:MGI:2149712
See related
Ensembl:ENSMUSG00000036523 AllianceGenome:MGI:2149712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0575; 9130004E13; 5730583K22Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; incisor; retina nuclear layer; and tail unsegmented mesenchyme. Orthologous to human GREB1 (growth regulating estrogen receptor binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 76.5), adrenal adult (RPKM 16.0) and 1 other tissue See more
Orthologs
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Genomic context

See Greb1 in Genome Data Viewer
Location:
12 A1.1; 12 8.0 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16720616..16851395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16670615..16801394, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31639 Neighboring gene lipin 1 Neighboring gene STARR-seq mESC enhancer starr_31643 Neighboring gene STARR-positive B cell enhancer ABC_E11503 Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene neurotensin receptor 2 Neighboring gene STARR-seq mESC enhancer starr_31647 Neighboring gene E2F transcription factor 6 Neighboring gene predicted gene, 36495

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252071.1NP_001239000.1  protein GREB1 isoform 2

    See identical proteins and their annotated locations for NP_001239000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122228, CN536594
    Consensus CDS
    CCDS56830.1
    UniProtKB/TrEMBL
    E0CXG4
    Related
    ENSMUSP00000125339.2, ENSMUST00000159120.8
    Conserved Domains (1) summary
    pfam15782
    Location:11926
    GREB1; Gene regulated by oestrogen in breast cancer
  2. NM_015764.4NP_056579.2  protein GREB1 isoform 1

    See identical proteins and their annotated locations for NP_056579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122228, AC157352, CJ098754, CJ099922, CN536594
    Consensus CDS
    CCDS36408.1
    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Related
    ENSMUSP00000124348.2, ENSMUST00000162112.8
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16720616..16851395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515101.5XP_006515164.1  protein GREB1 isoform X4

    Conserved Domains (1) summary
    pfam15782
    Location:11858
    GREB1; Gene regulated by oestrogen in breast cancer
  2. XM_006515096.4XP_006515159.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515159.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer
  3. XM_006515100.4XP_006515163.1  protein GREB1 isoform X3

    See identical proteins and their annotated locations for XP_006515163.1

    UniProtKB/TrEMBL
    E0CXG4
    Conserved Domains (1) summary
    pfam15782
    Location:11926
    GREB1; Gene regulated by oestrogen in breast cancer
  4. XM_006515099.4XP_006515162.1  protein GREB1 isoform X2

    Conserved Domains (1) summary
    pfam15782
    Location:11953
    GREB1; Gene regulated by oestrogen in breast cancer
  5. XM_006515093.4XP_006515156.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515156.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer
  6. XM_006515097.3XP_006515160.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515160.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer
  7. XM_006515094.3XP_006515157.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515157.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Related
    ENSMUSP00000044454.10, ENSMUST00000048064.16
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer
  8. XM_006515095.3XP_006515158.1  protein GREB1 isoform X1

    See identical proteins and their annotated locations for XP_006515158.1

    UniProtKB/Swiss-Prot
    E0CYB3, Q3UHK3, Q8BZT6, Q8CHE7, Q9JLG7
    Conserved Domains (1) summary
    pfam15782
    Location:11954
    GREB1; Gene regulated by oestrogen in breast cancer
  9. XM_030246728.1XP_030102588.1  protein GREB1 isoform X5

    Conserved Domains (1) summary
    pfam15782
    Location:11070
    GREB1; Gene regulated by oestrogen in breast cancer
  10. XM_006515107.4XP_006515170.1  protein GREB1 isoform X10

    Conserved Domains (1) summary
    pfam15782
    Location:1612
    GREB1; Gene regulated by oestrogen in breast cancer
  11. XM_006515106.4XP_006515169.1  protein GREB1 isoform X9

    Conserved Domains (1) summary
    pfam15782
    Location:1612
    GREB1; Gene regulated by oestrogen in breast cancer
  12. XM_006515105.4XP_006515168.1  protein GREB1 isoform X8

    Conserved Domains (1) summary
    pfam15782
    Location:1612
    GREB1; Gene regulated by oestrogen in breast cancer
  13. XM_006515104.4XP_006515167.1  protein GREB1 isoform X7

    Conserved Domains (1) summary
    pfam15782
    Location:1750
    GREB1; Gene regulated by oestrogen in breast cancer
  14. XM_006515103.4XP_006515166.1  protein GREB1 isoform X6

    Conserved Domains (1) summary
    pfam15782
    Location:1750
    GREB1; Gene regulated by oestrogen in breast cancer

RNA

  1. XR_004937504.1 RNA Sequence

  2. XR_381189.5 RNA Sequence

  3. XR_872413.4 RNA Sequence

  4. XR_381190.4 RNA Sequence

  5. XR_381191.4 RNA Sequence