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Eme1 essential meiotic structure-specific endonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 268465, updated on 9-Sep-2018

Summary

Official Symbol
Eme1provided by MGI
Official Full Name
essential meiotic structure-specific endonuclease 1provided by MGI
Primary source
MGI:MGI:3576783
See related
Ensembl:ENSMUSG00000039055 Vega:OTTMUSG00000002020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6820428D13
Expression
Broad expression in CNS E11.5 (RPKM 17.9), cortex adult (RPKM 15.1) and 26 other tissues See more
Orthologs

Genomic context

See Eme1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (94644998..94653785, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (94506316..94515068, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene chondroadherin Neighboring gene leucine rich repeat containing 59 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase II Neighboring gene predicted gene 11541

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC106543

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to crossover junction endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-S DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
crossover junction endonuclease EME1
Names
essential meiotic endonuclease 1 homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177752.5NP_808420.1  crossover junction endonuclease EME1

    See identical proteins and their annotated locations for NP_808420.1

    Status: VALIDATED

    Source sequence(s)
    AL645764
    Consensus CDS
    CCDS25262.1
    UniProtKB/Swiss-Prot
    Q8BJW7
    Related
    ENSMUSP00000036361.4, OTTMUSP00000001959, ENSMUST00000039949.4
    Conserved Domains (2) summary
    pfam02732
    Location:271439
    ERCC4; ERCC4 domain
    pfam07304
    Location:56115
    SRA1; Steroid receptor RNA activator (SRA1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    94644998..94653785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249045.1XP_011247347.1  crossover junction endonuclease EME1 isoform X2

    Conserved Domains (1) summary
    pfam02732
    Location:148197
    ERCC4; ERCC4 domain
  2. XM_006533408.2XP_006533471.1  crossover junction endonuclease EME1 isoform X1

    Conserved Domains (2) summary
    pfam02732
    Location:409458
    ERCC4; ERCC4 domain
    pfam07304
    Location:56115
    SRA1; Steroid receptor RNA activator (SRA1)
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