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Ankrd13b ankyrin repeat domain 13b [ Mus musculus (house mouse) ]

Gene ID: 268445, updated on 11-Feb-2023

Summary

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Official Symbol
Ankrd13bprovided by MGI
Official Full Name
ankyrin repeat domain 13bprovided by MGI
Primary source
MGI:MGI:2144501
See related
Ensembl:ENSMUSG00000037907 AllianceGenome:MGI:2144501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930093C12Rik
Summary
Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13B (ankyrin repeat domain 13B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 67.5), CNS E14 (RPKM 58.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd13b in Genome Data Viewer
Location:
11; 11 B5
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77361311..77380868, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77470485..77490042, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene VISTA enhancer mm146 Neighboring gene microRNA mir-12181 Neighboring gene coronin 6 Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene GIT ArfGAP 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Siletti K, et al. Proc Natl Acad Sci U S A, 2017 Dec 26. PMID 29229865, Free PMC Article
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373882.1 → NP_001360811.1  ankyrin repeat domain-containing protein 13B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS88195.1
    UniProtKB/Swiss-Prot
    Q6IR40
    Related
    ENSMUSP00000073584.7, ENSMUST00000037593.14
    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001373883.1 → NP_001360812.1  ankyrin repeat domain-containing protein 13B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_172945.2 → NP_766533.2  ankyrin repeat domain-containing protein 13B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607072, CA315262, CA329030, CD578820, CJ131946
    Consensus CDS
    CCDS36233.1
    UniProtKB/Swiss-Prot
    Q5F259
    Related
    ENSMUSP00000090568.4, ENSMUST00000092892.10
    Conserved Domains (4) summary
    PHA02682
    Location:620 → 675
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77361311..77380868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533397.4 → XP_006533460.1  ankyrin repeat domain-containing protein 13B isoform X12

    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036156714.1 → XP_036012607.1  ankyrin repeat domain-containing protein 13B isoform X9

    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006533389.4 → XP_006533452.1  ankyrin repeat domain-containing protein 13B isoform X3

    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036156715.1 → XP_036012608.1  ankyrin repeat domain-containing protein 13B isoform X14

    Conserved Domains (1) summary
    pfam11904
    Location:1 → 98
    GPCR_chapero_1; GPCR-chaperone

  5. XM_006533398.5 → XP_006533461.1  ankyrin repeat domain-containing protein 13B isoform X13

    Conserved Domains (3) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006533394.4 → XP_006533457.1  ankyrin repeat domain-containing protein 13B isoform X10

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_006533396.4 → XP_006533459.1  ankyrin repeat domain-containing protein 13B isoform X11

    See identical proteins and their annotated locations for XP_006533459.1

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_011249039.3 → XP_011247341.1  ankyrin repeat domain-containing protein 13B isoform X5

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_011249040.3 → XP_011247342.1  ankyrin repeat domain-containing protein 13B isoform X6

    Conserved Domains (4) summary
    PRK07003
    Location:441 → 702
    PRK07003; DNA polymerase III subunit gamma/tau
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_006533390.4 → XP_006533453.1  ankyrin repeat domain-containing protein 13B isoform X4

    Conserved Domains (4) summary
    PHA02682
    Location:713 → 768
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_011249041.3 → XP_011247343.1  ankyrin repeat domain-containing protein 13B isoform X7

    Conserved Domains (5) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:362 → 667
    Hamartin; Hamartin protein
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_011249038.3 → XP_011247340.1  ankyrin repeat domain-containing protein 13B isoform X2

    Conserved Domains (4) summary
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam04388
    Location:362 → 675
    Hamartin; Hamartin protein
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_006533388.4 → XP_006533451.1  ankyrin repeat domain-containing protein 13B isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:411 → 838
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  14. XM_006533392.4 → XP_006533455.1  ankyrin repeat domain-containing protein 13B isoform X8

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  15. XM_011249042.3 → XP_011247344.1  ankyrin repeat domain-containing protein 13B isoform X11

    See identical proteins and their annotated locations for XP_011247344.1

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

  16. XM_011249043.4 → XP_011247345.1  ankyrin repeat domain-containing protein 13B isoform X11

    See identical proteins and their annotated locations for XP_011247345.1

    Conserved Domains (4) summary
    PHA02682
    Location:427 → 504
    PHA02682; ORF080 virion core protein; Provisional
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:163 → 368
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:18 → 101
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_001780009.3 RNA Sequence

  2. XR_388467.4 RNA Sequence

  3. XR_388468.4 RNA Sequence

  4. XR_004936971.1 RNA Sequence

  5. XR_004936970.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F259.1 GenPept UniProtKB/Swiss-Prot:Q5F259

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