U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ppia peptidylprolyl isomerase A [ Mus musculus (house mouse) ]

Gene ID: 268373, updated on 1-Mar-2024

Summary

Official Symbol
Ppiaprovided by MGI
Official Full Name
peptidylprolyl isomerase Aprovided by MGI
Primary source
MGI:MGI:97749
See related
Ensembl:ENSMUSG00000071866 AllianceGenome:MGI:97749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cphn; CypA; SP18; CyP-18
Summary
Enables integrin binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in platelet aggregation. Acts upstream of or within neuron differentiation. Located in extracellular space and myelin sheath. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 1110.7), CNS E11.5 (RPKM 1109.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ppia in Genome Data Viewer
Location:
11 A1; 11 3.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6365867..6369817)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6415867..6419817)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28459 Neighboring gene STARR-seq mESC enhancer starr_28461 Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene microRNA 7651 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene H2A.Z histone variant 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene 60S ribosomal protein L36a-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid droplet organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase A
Names
PPIase A
cyclophilin A
cyclosporin A-binding protein
rotamase A
NP_032933.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008907.2NP_032933.1  peptidyl-prolyl cis-trans isomerase A

    See identical proteins and their annotated locations for NP_032933.1

    Status: VALIDATED

    Source sequence(s)
    AK160780
    Consensus CDS
    CCDS24419.1
    UniProtKB/Swiss-Prot
    P17742, Q9CWJ5, Q9R137
    UniProtKB/TrEMBL
    Q3TE63, Q3UAJ1, Q5SVY2
    Related
    ENSMUSP00000117987.2, ENSMUST00000132846.2
    Conserved Domains (1) summary
    cd01926
    Location:4162
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6365867..6369817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)