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OR2H1 olfactory receptor family 2 subfamily H member 1 [ Homo sapiens (human) ]

Gene ID: 26716, updated on 11-Jun-2021

Summary

Official Symbol
OR2H1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily H member 1provided by HGNC
Primary source
HGNC:HGNC:8252
See related
Ensembl:ENSG00000204688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2H6; OR2H8; OR6-2; 6M1-16; HS6M1-16; dJ994E9.4; OLFR42A-9004-14; OLFR42A-9004.14/9026.2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.9) See more
Orthologs
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Genomic context

See OR2H1 in Genome Data Viewer
Location:
6p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (29457133..29464328)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29424932..29432105)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily V member 1 Neighboring gene olfactory receptor family 12 subfamily D member 1 (gene/pseudogene) Neighboring gene olfactory receptor family 11 subfamily A member 1 Neighboring gene uncharacterized LOC105379641 Neighboring gene olfactory receptor family 10 subfamily C member 1 Neighboring gene ubiquitin D pseudogene 1 Neighboring gene MAS1L pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2H1
Names
olfactory receptor 2H6
olfactory receptor 2H8
olfactory receptor 6-2
olfactory receptor OR6-32
olfactory receptor, family 2, subfamily H, member 6
olfactory receptor, family 2, subfamily H, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318014.2NP_001304943.1  olfactory receptor 2H1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL645927, BC036097, BC048991, DB035138, DB457588
    Consensus CDS
    CCDS4660.1
    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001318022.2NP_001304951.1  olfactory receptor 2H1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and an alternate exon in the 5' UTR compared to variant 1. Variants 1,2, and 3 encode the same protein.
    Source sequence(s)
    AL645927, BC036097, BC048991, DB457588, HY005013
    Consensus CDS
    CCDS4660.1
    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_030883.5NP_112145.1  olfactory receptor 2H1

    See identical proteins and their annotated locations for NP_112145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL645927, BC036097, BC048991, DB053988, DB457588
    Consensus CDS
    CCDS4660.1
    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Related
    ENSP00000366337.1, ENST00000377133.6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    29457133..29464328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010739.1XP_016866228.1  olfactory receptor 2H1 isoform X1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Related
    ENSP00000366336.1, ENST00000377132.1
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017010737.1XP_016866226.1  olfactory receptor 2H1 isoform X1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017010738.1XP_016866227.1  olfactory receptor 2H1 isoform X1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_024446402.1XP_024302170.1  olfactory receptor 2H1 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1840
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1214
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_011514470.2XP_011512772.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512772.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_011514473.2XP_011512775.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512775.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_011514472.2XP_011512774.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512774.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. XM_011514479.2XP_011512781.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512781.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. XM_011514483.2XP_011512785.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512785.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. XM_011514484.2XP_011512786.1  olfactory receptor 2H1 isoform X1

    See identical proteins and their annotated locations for XP_011512786.1

    UniProtKB/Swiss-Prot
    Q9GZK4
    UniProtKB/TrEMBL
    A0A024RCM6
    Conserved Domains (1) summary
    cd15947
    Location:23292
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    722815..729989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    943608..950780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    722678..729851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    722279..729453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    722529..729702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    722620..729794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    766168..773341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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