ccnf cyclin F [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccnfprovided by ZNC
Official Full Name: cyclin Fprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021030-2
See related: Ensembl:ENSDARG00000105046 AllianceGenome:ZFIN:ZDB-GENE-021030-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb443; zgc:77240
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of centrosome duplication; and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within cell division. Predicted to be located in centriole. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in several structures, including margin; nervous system; optic vesicle; tail bud; and ventral mesoderm. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (12554801..12586614)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (12401858..12433671)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Title: Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Cyclin F can alter the turnover of TDP-43.
Title: Cyclin F can alter the turnover of TDP-43.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.