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ADGRF1 adhesion G protein-coupled receptor F1 [ Homo sapiens (human) ]

Gene ID: 266977, updated on 22-Sep-2022

Summary

Official Symbol
ADGRF1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F1provided by HGNC
Primary source
HGNC:HGNC:18990
See related
Ensembl:ENSG00000153292 MIM:617430; AllianceGenome:HGNC:18990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR19; GPR110; KPG_012; hGPCR36
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues See more
Orthologs
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Genomic context

See ADGRF1 in Genome Data Viewer
Location:
6p12.3; 6
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (46997708..47042332, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (46835188..46879812, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46965445..47010068, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene uncharacterized LOC105375080 Neighboring gene uncharacterized LOC124901489 Neighboring gene Sharpr-MPRA regulatory region 10363 Neighboring gene uncharacterized LOC105375081

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22684, FLJ30646, MGC125952

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cannabinoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor F1
Names
G protein-coupled receptor 110
G protein-coupled receptor PGR19
G-protein coupled receptor KPG_012
probable G-protein coupled receptor 110
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025048.4NP_079324.2  adhesion G-protein coupled receptor F1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_079324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3'-terminal exon, compared to variant 1, resulting in the shorter isoform (2) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AB045123, AK026337, AK095348, BC104214
    Consensus CDS
    CCDS4920.1
    UniProtKB/Swiss-Prot
    Q5T601
    UniProtKB/TrEMBL
    Q3SXM8
    Related
    ENSP00000360289.2, ENST00000371243.2
    Conserved Domains (1) summary
    pfam01390
    Location:154204
    SEA; SEA domain
  2. NM_153840.4NP_722582.2  adhesion G-protein coupled receptor F1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_722582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB045123, AK095348, AL355518, AY140952
    Consensus CDS
    CCDS34471.1
    UniProtKB/Swiss-Prot
    Q5T601, Q9H615
    Related
    ENSP00000360299.2, ENST00000371253.7
    Conserved Domains (3) summary
    pfam01390
    Location:154215
    SEA; SEA domain
    pfam01825
    Location:532572
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:582834
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    46997708..47042332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418639.1XP_047274595.1  adhesion G-protein coupled receptor F1 isoform X1

    Related
    ENSP00000283297.5, ENST00000283297.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    46835188..46879812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)