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ADGRF1 adhesion G protein-coupled receptor F1 [ Homo sapiens (human) ]

Gene ID: 266977, updated on 21-Dec-2019

Summary

Official Symbol
ADGRF1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F1provided by HGNC
Primary source
HGNC:HGNC:18990
See related
Ensembl:ENSG00000153292 MIM:617430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR19; GPR110; KPG_012; hGPCR36
Expression
Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues See more
Orthologs

Genomic context

See ADGRF1 in Genome Data Viewer
Location:
6p12.3; 6
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46997708..47042350, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46967116..47010082, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080 Neighboring gene Sharpr-MPRA regulatory region 10363 Neighboring gene uncharacterized LOC105375081

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ22684, FLJ30646, MGC125952

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CREB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G-protein coupled receptor F1
Names
G protein-coupled receptor 110
G protein-coupled receptor PGR19
G-protein coupled receptor KPG_012
probable G-protein coupled receptor 110
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025048.4NP_079324.2  adhesion G-protein coupled receptor F1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_079324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3'-terminal exon, compared to variant 1, resulting in the shorter isoform (2) with a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AB045123, AK026337, AK095348, BC104214
    Consensus CDS
    CCDS4920.1
    UniProtKB/Swiss-Prot
    Q5T601
    UniProtKB/TrEMBL
    Q3SXM8
    Related
    ENSP00000360289.2, ENST00000371243.2
    Conserved Domains (1) summary
    pfam01390
    Location:154204
    SEA; SEA domain
  2. NM_153840.4NP_722582.2  adhesion G-protein coupled receptor F1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_722582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB045123, AK095348, AL355518, AY140952
    Consensus CDS
    CCDS34471.1
    UniProtKB/Swiss-Prot
    Q5T601
    Related
    ENSP00000360299.2, ENST00000371253.7
    Conserved Domains (3) summary
    pfam01390
    Location:154215
    SEA; SEA domain
    pfam01825
    Location:532572
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:582834
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46997708..47042350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010735.1XP_016866224.1  adhesion G-protein coupled receptor F1 isoform X1

    Conserved Domains (2) summary
    pfam01825
    Location:336376
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:386638
    7tm_4; Olfactory receptor
  2. XM_017010736.2XP_016866225.1  adhesion G-protein coupled receptor F1 isoform X2

    Conserved Domains (3) summary
    smart00303
    Location:220263
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:273297
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:270538
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_024446401.1XP_024302169.1  adhesion G-protein coupled receptor F1 isoform X2

    Conserved Domains (3) summary
    smart00303
    Location:220263
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:273297
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:270538
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_011514469.1XP_011512771.1  adhesion G-protein coupled receptor F1 isoform X1

    Related
    ENSP00000283297.5, ENST00000283297.5
    Conserved Domains (2) summary
    pfam01825
    Location:336376
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:386638
    7tm_4; Olfactory receptor
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