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OR2V1 olfactory receptor family 2 subfamily V member 1 [ Homo sapiens (human) ]

Gene ID: 26693, updated on 2-Nov-2024

Summary

Official Symbol
OR2V1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily V member 1provided by HGNC
Primary source
HGNC:HGNC:8280
See related
Ensembl:ENSG00000185372 AllianceGenome:HGNC:8280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2V1P; OST265
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2V1 in Genome Data Viewer
Location:
5q35.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (181123122..181131169, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181683156..181691193, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180550122..180558169, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val (anticodon CAC) 1-3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180531361-180531862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180531863-180532362 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180556955-180557456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180565055-180565554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180574489-180575211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180577953-180578454 Neighboring gene olfactory receptor family 2 subfamily V member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180586450-180587206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180587207-180587962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23778 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180588627-180588969 Neighboring gene Sharpr-MPRA regulatory region 11855 Neighboring gene tRNA-Val (anticodon AAC) 1-2

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 2V1
Names
olfactory receptor, family 2, subfamily V, member 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258283.2NP_001245212.1  olfactory receptor 2V1

    See identical proteins and their annotated locations for NP_001245212.1

    Status: VALIDATED

    Source sequence(s)
    AC008620
    Consensus CDS
    CCDS58992.1
    UniProtKB/Swiss-Prot
    Q8NHB1
    UniProtKB/TrEMBL
    A0A126GWQ1
    Related
    ENSP00000492946.1, ENST00000641551.1
    Conserved Domains (2) summary
    pfam00001
    Location:42291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35306
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    181123122..181131169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181683156..181691193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004137.3: Suppressed sequence

    Description
    NG_004137.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.