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GEM GTP binding protein overexpressed in skeletal muscle [ Homo sapiens (human) ]

Gene ID: 2669, updated on 18-Sep-2024

Summary

Official Symbol
GEMprovided by HGNC
Official Full Name
GTP binding protein overexpressed in skeletal muscleprovided by HGNC
Primary source
HGNC:HGNC:4234
See related
Ensembl:ENSG00000164949 MIM:600164; AllianceGenome:HGNC:4234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIR
Summary
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 114.4), urinary bladder (RPKM 36.5) and 15 other tissues See more
Orthologs
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Genomic context

See GEM in Genome Data Viewer
Location:
8q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94249253..94262319, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95374122..95387192, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95261481..95274547, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cadherin 17 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:95218310-95219509 Neighboring gene ribosomal protein L6 pseudogene 23 Neighboring gene uncharacterized LOC105375648 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95246124-95246703 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95246704-95247282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:95247283-95247861 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:95272504-95272647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19365 Neighboring gene uncharacterized LOC107986896 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:95319922-95321121 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:95353266-95353915 Neighboring gene ribosomal protein S4X pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of GTP binding protein overexpressed in skeletal muscle (GEM) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC26294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein GEM
Names
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
kinase-inducible Ras-like protein
NP_005252.1
NP_859053.1
XP_016868804.1
XP_047277642.1
XP_054216253.1
XP_054216254.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005261.4NP_005252.1  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_005252.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003478, BC022010, DB018783
    Consensus CDS
    CCDS6261.1
    UniProtKB/Swiss-Prot
    B2RA31, P55040
    Related
    ENSP00000297596.2, ENST00000297596.3
    Conserved Domains (1) summary
    cd04148
    Location:76296
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
  2. NM_181702.3NP_859053.1  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_859053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003478, BC022010
    Consensus CDS
    CCDS6261.1
    UniProtKB/Swiss-Prot
    B2RA31, P55040
    Related
    ENSP00000379497.2, ENST00000396194.6
    Conserved Domains (1) summary
    cd04148
    Location:76296
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94249253..94262319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421686.1XP_047277642.1  GTP-binding protein GEM isoform X1

  2. XM_017013315.2XP_016868804.1  GTP-binding protein GEM isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    95374122..95387192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360279.1XP_054216254.1  GTP-binding protein GEM isoform X1

  2. XM_054360278.1XP_054216253.1  GTP-binding protein GEM isoform X1