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GEM GTP binding protein overexpressed in skeletal muscle [ Homo sapiens (human) ]

Gene ID: 2669, updated on 7-Dec-2018

Summary

Official Symbol
GEMprovided by HGNC
Official Full Name
GTP binding protein overexpressed in skeletal muscleprovided by HGNC
Primary source
HGNC:HGNC:4234
See related
Ensembl:ENSG00000164949 MIM:600164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIR
Summary
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 114.4), urinary bladder (RPKM 36.5) and 15 other tissues See more
Orthologs

Genomic context

See GEM in Genome Data Viewer
Location:
8q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (94249249..94262345, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95261481..95274547, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cadherin 17 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene uncharacterized LOC105375648 Neighboring gene uncharacterized LOC107986896 Neighboring gene ribosomal protein S4X pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of GTP binding protein overexpressed in skeletal muscle (GEM) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein GEM
Names
GTP-binding mitogen-induced T-cell protein
RAS-like protein KIR
kinase-inducible Ras-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005261.4NP_005252.1  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_005252.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003478, BC022010, DB018783
    Consensus CDS
    CCDS6261.1
    UniProtKB/Swiss-Prot
    P55040
    UniProtKB/TrEMBL
    A0A024R9F5
    Related
    ENSP00000297596.2, ENST00000297596.2
    Conserved Domains (1) summary
    cd04148
    Location:76296
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
  2. NM_181702.2NP_859053.1  GTP-binding protein GEM

    See identical proteins and their annotated locations for NP_859053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003478, BC022010
    Consensus CDS
    CCDS6261.1
    UniProtKB/Swiss-Prot
    P55040
    UniProtKB/TrEMBL
    A0A024R9F5
    Related
    ENSP00000379497.2, ENST00000396194.6
    Conserved Domains (1) summary
    cd04148
    Location:76296
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    94249249..94262345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013315.1XP_016868804.1  GTP-binding protein GEM isoform X1

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