Format

Send to:

Choose Destination

prdx-2 PeRoxireDoXin [ Caenorhabditis elegans ]

Gene ID: 266858, updated on 4-Dec-2018

Summary

Gene symbol
prdx-2
Gene description
PeRoxireDoXin
Primary source
WormBase:WBGene00006434
Locus tag
CELE_F09E5.15
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See prdx-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (5378195..5379493)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative deoxyribose-phosphate aldolase Neighboring gene Asparagine Linked Glycosylation (ALG) homolog, Nematode Neighboring gene ncRNA Neighboring gene Protein kinase C-like 3

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to metal ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PeRoxireDoXin
NP_001122604.1
  • Product from WormBase gene class prdx;
    Confirmed by transcript evidence
NP_001300536.1
  • Product from WormBase gene class prdx;
    Partially confirmed by transcript evidence
NP_872052.1
  • Product from WormBase gene class prdx;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5378195..5379493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129132.2NP_001122604.1  PeRoxireDoXin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZL7
    Conserved Domains (2) summary
    COG0450
    Location:9199
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:10181
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_001313607.1NP_001300536.1  PeRoxireDoXin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUJ9
    Conserved Domains (2) summary
    COG0450
    Location:11201
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:12183
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  3. NM_182252.5NP_872052.1  PeRoxireDoXin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IG31
    Conserved Domains (2) summary
    COG0450
    Location:5195
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:6177
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Support Center