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top-1 DNA topoisomerase 1 [ Caenorhabditis elegans ]

Gene ID: 266847, updated on 22-May-2018
Gene symbol
top-1
Gene description
DNA topoisomerase 1
Primary source
WormBase:WBGene00006595
Locus tag
CELE_M01E5.5
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
See top-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (13292626..13296867)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity IEA
Inferred from Electronic Annotation
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
DNA topoisomerase 1
NP_001021578.1
  • Confirmed by transcript evidence
NP_493337.1
  • Confirmed by transcript evidence

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13292626..13296867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060936.5NP_493337.1  DNA topoisomerase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17966
    Conserved Domains (4) summary
    smart00435
    Location:402775
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:258472
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:474684
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:733795
    Topo_C_assoc; C-terminal topoisomerase domain
  2. NM_001026407.5NP_001021578.1  DNA topoisomerase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021578.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17966
    Conserved Domains (4) summary
    smart00435
    Location:330703
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03488
    Location:186400
    Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
    pfam01028
    Location:402612
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:661723
    Topo_C_assoc; C-terminal topoisomerase domain
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