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Prrx1 paired related homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266813, updated on 30-Sep-2021

Summary

Official Symbol
Prrx1provided by RGD
Official Full Name
paired related homeobox 1provided by RGD
Primary source
RGD:628884
See related
EnsemblRapid:ENSRNOG00000003720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pmx1; Prx-1
Summary
binds the collagen I alpha 1 and the osteocalcin promoters; acts as a negative regulator of transcription [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 83.8), Uterus (RPKM 57.3) and 8 other tissues See more
Orthologs
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Genomic context

See Prrx1 in Genome Data Viewer
Location:
13q22
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75600777..75671896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (81147038..81215559, complement)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene uncharacterized LOC120096300 Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 8 Neighboring gene golgin, RAB6-interacting

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair by transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
paired mesoderm homeobox protein 1
Names
paired mesoderm homeobox 1
paired-related homeobox protein 1
rHox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153821.2NP_722543.1  paired mesoderm homeobox protein 1

    See identical proteins and their annotated locations for NP_722543.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000244
    UniProtKB/Swiss-Prot
    P63014
    Related
    ENSRNOP00000075169.2, ENSRNOT00000082385.2
    Conserved Domains (2) summary
    pfam00046
    Location:99151
    Homeobox; Homeobox domain
    pfam03826
    Location:219235
    OAR; OAR domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    75600777..75671896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250151.4XP_006250213.1  paired mesoderm homeobox protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006250213.1

    UniProtKB/Swiss-Prot
    P63014
    Related
    ENSRNOP00000004950.5, ENSRNOT00000004950.7
    Conserved Domains (1) summary
    pfam00046
    Location:99151
    Homeobox; Homeobox domain
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