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NAP1L5 nucleosome assembly protein 1 like 5 [ Homo sapiens (human) ]

Gene ID: 266812, updated on 1-Aug-2020

Summary

Official Symbol
NAP1L5provided by HGNC
Official Full Name
nucleosome assembly protein 1 like 5provided by HGNC
Primary source
HGNC:HGNC:19968
See related
Ensembl:ENSG00000177432 MIM:612203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRLM
Summary
This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]
Orthologs

Genomic context

See NAP1L5 in Genome Data Viewer
Location:
4q22.1; 4q21-q22
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (88695913..88697829, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89617066..89619023, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 3 Neighboring gene RN7SK pseudogene 244 Neighboring gene RNA, U6 small nuclear 33, pseudogene Neighboring gene FAM13A antisense RNA 1 Neighboring gene HNF1 motif-containing MPRA enhancer 87 Neighboring gene family with sequence similarity 13 member A

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleosome assembly protein 1-like 5
Names
down-regulated in liver malignancy

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_045229.1 RefSeqGene

    Range
    5407..7323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153757.4NP_715638.1  nucleosome assembly protein 1-like 5

    See identical proteins and their annotated locations for NP_715638.1

    Status: REVIEWED

    Source sequence(s)
    AK054689, BC039416, CK301058, DA041186
    Consensus CDS
    CCDS3632.1
    UniProtKB/Swiss-Prot
    Q96NT1
    Related
    ENSP00000320488.5, ENST00000323061.7
    Conserved Domains (1) summary
    cl08298
    Location:80119
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    88695913..88697829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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