Sostdc1 sclerostin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sostdc1provided by RGD
Official Full Name: sclerostin domain containing 1provided by RGD
Primary source: RGD:628877
See related: Ensembl:ENSRNOG00000005770 AllianceGenome:RGD:628877
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wise; Usag1; Usag-1
Summary: Predicted to enable BMP binding activity and BMP receptor activity. Predicted to be involved in negative regulation of determination of dorsal identity; negative regulation of myoblast differentiation; and negative regulation of signal transduction. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; negative regulation of canonical Wnt signaling pathway; and odontogenesis of dentin-containing tooth. Predicted to be active in extracellular space. Orthologous to human SOSTDC1 (sclerostin domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Kidney (RPKM 394.7), Brain (RPKM 28.2) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 6q16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (58778623..58782797)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (53051336..53055510)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (55812820..55816994)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway.
Title: MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway.
Downregulation of Sostdc1 in Testicular Sertoli Cells is Prerequisite for Onset of Robust Spermatogenesis at Puberty.
Title: Downregulation of Sostdc1 in Testicular Sertoli Cells is Prerequisite for Onset of Robust Spermatogenesis at Puberty.
miR-26a promoted fracture healing of rats with nonunion in vivo and osteogenic differentiation of mesenchymal stem cells in vitro, possibly by targeting SOSTDC1.
Title: MiR-26a promotes fracture healing of nonunion rats possibly by targeting SOSTDC1 and further activating Wnt/β-catenin signaling pathway.
Art is able to improve the renal function decline and renal fibrosis induced by UUO, which may be associated with the up-regulation of BMP-7 and down-regulation of USAG-1.
Title: Artesunate attenuates unilateral ureteral obstruction-induced renal fibrosis by regulating the expressions of bone morphogenetic protein-7 and uterine sensitization-associated gene-1 in rats.
WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis.
Title: Inhibition of WISE preserves renal allograft function.
Rat homologue of the Xenopus-secreted WNT modulator Wise is expressed in the dermal papilla and not in the non-inductive dermal sheath and was additionally expressed at high levels in the precortex and in the putative bulge region [WISE].
Title: The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.
Expression of Sostdc1 exhibits a ~10-fold increase at night in the rat pineal gland.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
we report the isolation, cloning, and characterization of a novel gene, uterine sensitization-associated gene-1 (UASG-1), that is preferentially expressed within the maximally sensitized/receptive rat endometrium
Title: Uterine sensitization-associated gene-1: a novel gene induced within the rat endometrium at the time of uterine receptivity/sensitization for the decidual cell reaction.

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General gene information

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Markers

Sostdc1 (e-PCR), detects polymorphism
- UniSTS:471847

UniSTS:464692 (e-PCR)
- UniSTS:464692

Sostdc1 (e-PCR), detects polymorphism
- UniSTS:464692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of determination of dorsal identity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sclerostin domain-containing protein 1

Names: context-dependent activator and inhibitor of Wnt signalling protein Wise; uterine sensitization-associated gene 1 protein; wnt-signaling modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153737.2 → NP_714959.2 sclerostin domain-containing protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q642G2, Q8CJA4

UniProtKB/TrEMBL

A6HBB2

Related

ENSRNOP00000008106.3, ENSRNOT00000008106.8

Conserved Domains (1) summary

pfam05463
Location:6 → 206

Sclerostin; Sclerostin (SOST)