gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gatmprovided by ZNC
Official Full Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-021015-1
See related: Ensembl:ENSDARG00000036239 AllianceGenome:ZFIN:ZDB-GENE-021015-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb409; zgc:65855; wu:fa08a06
Summary: Predicted to enable glycine amidinotransferase activity. Predicted to be involved in creatine biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial intermembrane space. Is expressed in several structures, including digestive system; mesoderm; musculature system; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	18	NC_133193.1 (159637..169641, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (35729..45735, complement)

Chromosome 18 - NC_133193.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The spatiotemporal expression pattern of gatm during zebrafish embryogenesis was revealed.
Title: Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fa08a06.s1 (e-PCR)
- UniSTS:202251

fc80h07.y1 (e-PCR)
- UniSTS:194578

AA542570 (e-PCR)
- UniSTS:205408

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables amidinotransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine amidinotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine amidinotransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine amidinotransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in creatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in creatine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine amidinotransferase, mitochondrial

Names: agat

NP_955825.1

EC 2.1.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.