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Nptx1 neuronal pentraxin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266777, updated on 12-Jan-2022

Summary

Official Symbol
Nptx1provided by RGD
Official Full Name
neuronal pentraxin 1provided by RGD
Primary source
RGD:628894
See related
Ensembl:ENSRNOG00000003741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of postsynaptic density assembly. Located in mitochondrion; neuron projection; and plasma membrane. Is active in glutamatergic synapse and synaptic cleft. Orthologous to human NPTX1 (neuronal pentraxin 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 209.4) and Lung (RPKM 10.8) See more
Orthologs
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Genomic context

See Nptx1 in Genome Data Viewer
Location:
10q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (104811107..104820358, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (108682637..108691592, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095223 Neighboring gene uncharacterized LOC103693491 Neighboring gene endonuclease V Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H, pseudogene 1 Neighboring gene regulatory associated protein of MTOR, complex 1 Neighboring gene uncharacterized LOC120095307

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axonogenesis involved in innervation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axonogenesis involved in innervation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic density assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal pentraxin-1
Names
47 kDa taipoxin-binding protein
NP-I
NP1
neuronal pentraxin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153735.4NP_714957.1  neuronal pentraxin-1 precursor

    See identical proteins and their annotated locations for NP_714957.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P47971
    Related
    ENSRNOP00000005067.6, ENSRNOT00000005067.7
    Conserved Domains (2) summary
    smart00159
    Location:222428
    PTX; Pentraxin / C-reactive protein / pentaxin family
    COG1196
    Location:52221
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    104811107..104820358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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