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Hspa4 heat shock protein family A (Hsp70) member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266759, updated on 18-Apr-2019

Summary

Official Symbol
Hspa4provided by RGD
Official Full Name
heat shock protein family A (Hsp70) member 4provided by RGD
Primary source
RGD:628878
See related
Ensembl:ENSRNOG00000016596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hsp70; irp94; Hsp110
Summary
heat shock protein; may have an important role following forebrain ischemia and may allow astrocytes to protect neurons [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 486.9), Adrenal (RPKM 469.5) and 9 other tissues See more
Orthologs

Genomic context

See Hspa4 in Genome Data Viewer
Location:
10q22
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38601624..38642397, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (38383101..38424016, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548961 Neighboring gene follistatin-like 4 Neighboring gene uncharacterized LOC108352083 Neighboring gene 60S ribosomal protein L14 pseudogene Neighboring gene similar to 40S ribosomal protein S2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
protein import into mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
response to heat IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock 70 kDa protein 4
Names
heat shock protein 4
heat shock protein family A member 4
ischemia responsive 94 kDa protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153629.1NP_705893.1  heat shock 70 kDa protein 4

    See identical proteins and their annotated locations for NP_705893.1

    Status: PROVISIONAL

    Source sequence(s)
    AF077354
    UniProtKB/Swiss-Prot
    O88600
    Related
    ENSRNOP00000023628.3, ENSRNOT00000023628.3
    Conserved Domains (2) summary
    cd11737
    Location:2384
    HSPA4_NBD; Nucleotide-binding domain of HSPA4
    pfam00012
    Location:3607
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    38601624..38642397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    36756477..36796741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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