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RGL4 ral guanine nucleotide dissociation stimulator like 4 [ Homo sapiens (human) ]

Gene ID: 266747, updated on 26-Nov-2021

Summary

Official Symbol
RGL4provided by HGNC
Official Full Name
ral guanine nucleotide dissociation stimulator like 4provided by HGNC
Primary source
HGNC:HGNC:31911
See related
Ensembl:ENSG00000159496 MIM:612214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rgr
Summary
This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 20.9), appendix (RPKM 6.7) and 23 other tissues See more
Orthologs
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Genomic context

See RGL4 in Genome Data Viewer
Location:
22q11.23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (23691013..23699168)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24033200..24041355)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene aspartate rich 1 Neighboring gene GUSB pseudogene 11 Neighboring gene argininosuccinate lyase pseudogene 1 Neighboring gene zinc finger protein 70 Neighboring gene V-set pre-B cell surrogate light chain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119678, MGC119680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ral-GDS-related protein
Names
Ral-GDS related protein Rgr
RalGDS related oncogene
ralGDS-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329424.3NP_001316353.1  ral-GDS-related protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000347
    UniProtKB/Swiss-Prot
    Q8IZJ4
    UniProtKB/TrEMBL
    Q3ZCN2
    Related
    ENSP00000402142.1, ENST00000423392.5
  2. NM_001329425.2NP_001316354.1  ral-GDS-related protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AY101396, HY101412
    UniProtKB/Swiss-Prot
    Q8IZJ4
    Conserved Domains (1) summary
    cl02485
    Location:588
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  3. NM_153615.2NP_705843.1  ral-GDS-related protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_705843.1

    Status: REVIEWED

    Source sequence(s)
    AP000347
    Consensus CDS
    CCDS13811.1
    UniProtKB/Swiss-Prot
    Q8IZJ4
    Related
    ENSP00000290691.5, ENST00000290691.10
    Conserved Domains (1) summary
    cd00155
    Location:216467
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    23691013..23699168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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