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HS6ST3 heparan sulfate 6-O-sulfotransferase 3 [ Homo sapiens (human) ]

Gene ID: 266722, updated on 23-Nov-2023


Official Symbol
HS6ST3provided by HGNC
Official Full Name
heparan sulfate 6-O-sulfotransferase 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000185352 MIM:609401; AllianceGenome:HGNC:19134
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]
Biased expression in brain (RPKM 5.5), urinary bladder (RPKM 1.6) and 3 other tissues See more
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Genomic context

See HS6ST3 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (96090107..96839562)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (95294349..96043658)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96742361..97491816)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5448 Neighboring gene Sharpr-MPRA regulatory region 4273 Neighboring gene MT-CYB pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96558977-96559478 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96606253-96607155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611347-96611848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611849-96612348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96666836-96667336 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:96693792-96694381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96705417-96705916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96741684-96742184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96742185-96742685 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96947250-96948184 Neighboring gene microRNA 4501 Neighboring gene AMMECR1 like pseudogene 1 Neighboring gene MPRA-validated peak2102 silencer Neighboring gene uncharacterized LOC124903195 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:97469055-97469812 Neighboring gene Sharpr-MPRA regulatory region 11714 Neighboring gene heat shock protein 90 alpha family class B member 6, pseudogene Neighboring gene long intergenic non-protein coding RNA 359 Neighboring gene TUB like protein 3 pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Genome-wide association study of diabetic retinopathy in a Taiwanese population.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • DKFZp761K2315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparan sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
heparan-sulfate 6-O-sulfotransferase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153456.4NP_703157.2  heparan-sulfate 6-O-sulfotransferase 3 precursor

    See identical proteins and their annotated locations for NP_703157.2

    Status: VALIDATED

    Source sequence(s)
    AL138816, AL158192, AL353581
    Consensus CDS
    Q5W0L0, Q68CW6, Q8IZP7
    ENSP00000365895.2, ENST00000376705.4
    Conserved Domains (1) summary
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060937.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)