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Cpne1 copine I [ Mus musculus (house mouse) ]

Gene ID: 266692, updated on 2-Oct-2018

Summary

Official Symbol
Cpne1provided by MGI
Official Full Name
copine Iprovided by MGI
Primary source
MGI:MGI:2386621
See related
Ensembl:ENSMUSG00000074643 Vega:OTTMUSG00000019746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4108; 1810028N16Rik
Summary
This gene encodes a protein that contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Its activity is also upregulated in mouse embryos. This gene and the gene for RNA binding motif protein 12 overlap at map location 2 H2. Two alternatively spliced variants that encode the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 29.7), limb E14.5 (RPKM 24.5) and 28 other tissues See more
Orthologs

Genomic context

See Cpne1 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (156071841..156111965, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (155897577..155937701, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39970 Neighboring gene sperm associated antigen 4 Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0765, KIAA4108

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170588.3NP_733467.1  copine-1

    See identical proteins and their annotated locations for NP_733467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA154646, AK028882, AK152323, BB873018, BC057554
    Consensus CDS
    CCDS16960.1
    UniProtKB/Swiss-Prot
    Q8C166
    UniProtKB/TrEMBL
    Q3U893
    Related
    ENSMUSP00000105237.2, OTTMUSP00000017195, ENSMUST00000109608.8, OTTMUST00000038382
    Conserved Domains (3) summary
    cd04047
    Location:137244
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:6123
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:250507
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
  2. NM_170590.3NP_733469.1  copine-1

    See identical proteins and their annotated locations for NP_733469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA154646, AK028882, BB873018, BC057554
    Consensus CDS
    CCDS16960.1
    UniProtKB/Swiss-Prot
    Q8C166
    Related
    ENSMUSP00000105236.2, OTTMUSP00000017203, ENSMUST00000109607.9, OTTMUST00000038403
    Conserved Domains (3) summary
    cd04047
    Location:137244
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:6123
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:250507
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    156071841..156111965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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