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SEC14L3 SEC14 like lipid binding 3 [ Homo sapiens (human) ]

Gene ID: 266629, updated on 11-Sep-2019

Summary

Official Symbol
SEC14L3provided by HGNC
Official Full Name
SEC14 like lipid binding 3provided by HGNC
Primary source
HGNC:HGNC:18655
See related
Ensembl:ENSG00000100012 MIM:612824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAP2
Summary
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SEC14L3 in Genome Data Viewer
Location:
22q12.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30447959..30472047, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30843946..30868034, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc transporter ZIP1-like Neighboring gene Sharpr-MPRA regulatory region 4237 Neighboring gene uncharacterized LOC105372991 Neighboring gene uncharacterized LOC107985579 Neighboring gene syndecan 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119366, MGC119367, MGC119368

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
SEC14-like protein 3
Names
SEC14-like 3
SEC14p-like protein TAP2
tocopherol-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027515.1 RefSeqGene

    Range
    5001..17819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257378.1NP_001244307.1  SEC14-like protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exons and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004832, AY158086, AY240872, BC101001, EL947765
    Consensus CDS
    CCDS58800.1
    UniProtKB/Swiss-Prot
    Q9UDX4
    UniProtKB/TrEMBL
    Q6XCI7
    Related
    ENSP00000385004.1, ENST00000402286.5
    Conserved Domains (1) summary
    smart00516
    Location:2168
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
  2. NM_001257379.1NP_001244308.1  SEC14-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001244308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004832, AY158086, AY240872, BC101002, EL947765
    Consensus CDS
    CCDS58801.1
    UniProtKB/Swiss-Prot
    Q9UDX4
    UniProtKB/TrEMBL
    Q6XCI7
    Related
    ENSP00000383896.1, ENST00000401751.5
    Conserved Domains (1) summary
    smart00516
    Location:17186
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
  3. NM_001257382.1NP_001244311.1  SEC14-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001244311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AY158086, AY240872, BC101003, EL947765
    Consensus CDS
    CCDS58801.1
    UniProtKB/Swiss-Prot
    Q9UDX4
    UniProtKB/TrEMBL
    Q495V9, Q6XCI7
    Conserved Domains (1) summary
    smart00516
    Location:17186
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
  4. NM_174975.4NP_777635.1  SEC14-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_777635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY158086, AY240872, BC101004, BE219833
    Consensus CDS
    CCDS13877.1
    UniProtKB/Swiss-Prot
    Q9UDX4
    UniProtKB/TrEMBL
    Q6XCI7
    Related
    ENSP00000215812.4, ENST00000215812.8
    Conserved Domains (2) summary
    smart00516
    Location:76245
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:1359
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30447959..30472047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530128.2XP_011528430.1  SEC14-like protein 3 isoform X1

    Related
    ENSP00000385941.1, ENST00000403066.5
    Conserved Domains (2) summary
    smart00516
    Location:76245
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:1359
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
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