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Ptpn9 protein tyrosine phosphatase, non-receptor type 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266611, updated on 7-Apr-2025

Summary

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Official Symbol
Ptpn9provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 9provided by RGD
Primary source
RGD:628726
See related
EnsemblRapid:ENSRNOG00000017600 AllianceGenome:RGD:628726
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Meg2
Summary
Enables protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and positive regulation of protein localization to plasma membrane. Predicted to be located in cytoplasm and neuron projection terminus. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Adrenal (RPKM 146.5), Lung (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn9 in Genome Data Viewer
Location:
8q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66286771..66368306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57391290..57472352)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61658851..61739458)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene snurportin 1 Neighboring gene uncharacterized LOC103693102 Neighboring gene uncharacterized LOC102553607 Neighboring gene uncharacterized LOC120094171 Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells. Wang X, et al. J Immunol, 2002 May 1. PMID 11971009
  2. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. Zhang D, et al. J Biol Chem, 2016 Nov 11. PMID 27655914, Free PMC Article
  3. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
  4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr AJ, et al. Cell, 2009 Jan 23. PMID 19167335, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation
    Title: The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 9
NP_001013058.1
XP_006243168.1
XP_038936852.1
XP_063121057.1
XP_063121058.1
XP_063121059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013040.1 → NP_001013058.1  tyrosine-protein phosphatase non-receptor type 9

    See identical proteins and their annotated locations for NP_001013058.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082041
    UniProtKB/Swiss-Prot
    Q641Z2, Q8K3Y9
    UniProtKB/TrEMBL
    A0A0G2K6A2, A6J4S3
    Related
    ENSRNOP00000084715.2, ENSRNOT00000114994.2
    Conserved Domains (4) summary
    smart00194
    Location:302 → 573
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00516
    Location:90 → 238
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:20 → 66
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:329 → 573
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66286771..66368306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243106.5 → XP_006243168.1  tyrosine-protein phosphatase non-receptor type 9 isoform X3

    Conserved Domains (4) summary
    smart00194
    Location:302 → 458
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00516
    Location:90 → 238
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:20 → 66
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:329 → 466
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_063264987.1 → XP_063121057.1  tyrosine-protein phosphatase non-receptor type 9 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6A2, A0A8I6A1V8
    Related
    ENSRNOP00000104151.1, ENSRNOT00000159051.1

  3. XM_039080924.2 → XP_038936852.1  tyrosine-protein phosphatase non-receptor type 9 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K6A2
    Related
    ENSRNOP00000023831.6, ENSRNOT00000023831.8
    Conserved Domains (3) summary
    smart00516
    Location:73 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:4 → 49
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd14543
    Location:282 → 552
    PTPc-N9; catalytic domain of tyrosine-protein phosphatase non-receptor type 9

  4. XM_063264989.1 → XP_063121059.1  tyrosine-protein phosphatase non-receptor type 9 isoform X5

  5. XM_063264988.1 → XP_063121058.1  tyrosine-protein phosphatase non-receptor type 9 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641Z2.1 GenPept UniProtKB/Swiss-Prot:Q641Z2

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