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CKAP2 cytoskeleton associated protein 2 [ Homo sapiens (human) ]

Gene ID: 26586, updated on 12-Oct-2019

Summary

Official Symbol
CKAP2provided by HGNC
Official Full Name
cytoskeleton associated protein 2provided by HGNC
Primary source
HGNC:HGNC:1990
See related
Ensembl:ENSG00000136108 MIM:611569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LB1; TMAP; se20-10
Summary
This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Expression
Broad expression in bone marrow (RPKM 15.6), testis (RPKM 14.9) and 24 other tissues See more
Orthologs

Genomic context

See CKAP2 in Genome Data Viewer
Location:
13q14.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (52455360..52476631)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53029495..53050763)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 1 Neighboring gene RNY4 pseudogene 24 Neighboring gene vacuolar protein sorting 36 homolog Neighboring gene long intergenic non-protein coding RNA 345 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10749, DKFZp686L1238

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoskeleton-associated protein 2
Names
CTCL tumor antigen se20-10
tumor- and microtubule-associated protein
tumor-associated microtubule-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098525.2NP_001091995.1  cytoskeleton-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001091995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AI499799, AY062261, BM541375, EC439890, Y15758
    Consensus CDS
    CCDS41893.1
    UniProtKB/Swiss-Prot
    Q8WWK9
    Related
    ENSP00000367276.4, ENST00000378037.9
    Conserved Domains (1) summary
    pfam15297
    Location:326673
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
  2. NM_001286686.1NP_001273615.1  cytoskeleton-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI499799, AK299083, AY062261, EC439890
    Consensus CDS
    CCDS66557.1
    UniProtKB/Swiss-Prot
    Q8WWK9
    Related
    ENSP00000417830.1, ENST00000490903.5
    Conserved Domains (1) summary
    pfam15297
    Location:277624
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
  3. NM_001286687.1NP_001273616.1  cytoskeleton-associated protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001273616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as CKAP2-s) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA308726, AY062262, BM541375
    Consensus CDS
    CCDS73578.1
    UniProtKB/Swiss-Prot
    Q8WWK9
    Related
    ENSP00000367273.2, ENST00000378034.7
    Conserved Domains (1) summary
    pfam15297
    Location:325492
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
  4. NM_018204.5NP_060674.3  cytoskeleton-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_060674.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI499799, AK022982, AY062261, EC439890
    Consensus CDS
    CCDS9435.1
    UniProtKB/Swiss-Prot
    Q8WWK9
    Related
    ENSP00000258607.5, ENST00000258607.10
    Conserved Domains (1) summary
    pfam15297
    Location:325672
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    52455360..52476631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535043.2XP_011533345.1  cytoskeleton-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15297
    Location:243590
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
  2. XM_005266344.4XP_005266401.1  cytoskeleton-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15297
    Location:278625
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
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